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ProteomicsRECQ5 mediates pre-rRNA processing in nucleolus
explore the biological function of RECQ5 in nucleolus
ORGANISM(S): Homo Sapiens 
2024-11-19 | PXD058022 |
ProteomicsThe novel pre-rRNA detection workflow “Riboprobing” identified a hitherto undescribed aberrant pre-rRNA
Ribosomes translate mRNA into proteins and are essential for every living organism. In eukaryotes both ribosomal subunits are rapidly assembled in a strict hierarchical order, starting in the nucleolus with transcription of a common precursor ribosomal RNA (pre-rRNA). This pre-rRNA encodes three of ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-29 | PXD047506 | Pride
Aberrant pre-rrna Primer extension Ribosome biogenesis Reverse transcription Pre-rrna processing 
TranscriptomicsSIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing [CLIP-Seq]
SIRT7 is an NAD+-dependent protein deacetylase with important roles in ribosome biogenesis and cell proliferation. Previous studies have established that SIRT7 is associated with RNA polymerase I, interacts with pre-rRNA and promotes rRNA synthesis. Here we show that SIRT7 is also associated with sn...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-76578 | biostudies-arrayexpress
ProteomicsBMAL1 associates with NOP58 in the nucleolus and contributes to pre-rRNA processing
The transcription factor BMAL1 is a core element of the circadian clock that contributes to cyclic control of genes transcribed by RNA polymerase II. By using biochemical cellular fractionation and immunofluorescence analyses we reveal a previously uncharacterized nucleolar localization for BMAL1. W...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-25 | PXD018946 | Pride
Bmal1 interactome Nucleolus Circadian clock Ribosome biogenesis 
GenomicsEffect of depletion of Sas10 in pre-rRNA processing
Effect of depletion of Sas10 in pre-rRNA processing
PRJNA1093028 | ENA
ProteomicsNuclear VCP-like 2 (NVL2)-associated complex
LC-MSMS analysis of NVL2-associated pre-60S complex. To obtain more insights into the molecular mechanism of this effects caused by the mutant NVL2 in pre-60S complexes,we searched for additional proteins that preferentially interact with the NVL2(E365Q/E682Q) in comparison with wild-type NVL2. Co-m...
ORGANISM(S): Homo Sapiens (human) 
2025-01-31 | PXD057741 | JPOST Repository
GenomicsSingle-nucleotide resolution mapping and quantification of pre-rRNA processing and modification dynamics
Single nucleotide resolution mapping and quantification of pre-rRNA processing and modification dynamics
PRJEB90082 | ENA
OtherSIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing [CLIP-Seq]
SIRT7 is an NAD+-dependent protein deacetylase with important roles in ribosome biogenesis and cell proliferation. Previous studies have established that SIRT7 is associated with RNA polymerase I, interacts with pre-rRNA and promotes rRNA synthesis. Here we show that SIRT7 is also associated with sn...
ORGANISM(S): Homo sapiens 
2016-01-07 | GSE76578 | GEO
Transcriptomicsapum23_col3
Gene expression analyses of three-week old soil grown wild-type (Col-3) and apum23-1 mutant. Expression profiling was conducted as an attempt to identify the genes differentially regulated in apum23-1 mutant This study was under taken to characterize a member of pumilio family, APUM23 in Arabidopsis...
ORGANISM(S): Arabidopsis thaliana 
2011-03-01 | E-GEOD-23940 | biostudies-arrayexpress
TranscriptomicsRrp5 binding at multiple sites coordinates pre-rRNA processing and assembly
The CRAC UV crosslinking technique identified numerous pre-rRNA binding sites for the large, highly conserved ribosome synthesis factor Rrp5. Intramolecular complementation has shown that the C-terminal domain (CTD) of Rrp5 is required for pre-rRNA cleavage at sites A0-A2 on the pathway of 18S rRNA ...
ORGANISM(S): Saccharomyces cerevisiae BY4741 
2013-10-14 | GSE47680 | GEO
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