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MetabolomicsInsulin Resistance-Associated Bifidobacterium longum Ameliorates Prediabetes via the 6-ketoLCA/TGR5/GLP-1 axis

Background Prediabetes, a global health concern characterized by insulin resistance (IR) and closely linked to obesity, was investigated in this study to identify key gut microbiota characteristics. The development of insulin resistance is associated with gut microbiota. Therefore, identifying ke...

2026-01-14 | MTBLS13684 | MetaboLights
MetabolomicsThe Impact of Ethnicity and Intra-Pancreatic Fat on the Postprandial Metabolome Response to Whey Protein in Overweight Asian Chinese and European Caucasian Women with Prediabetes
The 'Thin on the Outside Fat on the Inside' TOFI_Asia study found Asian Chinese to be more susceptible to Type 2 Diabetes (T2D) compared to European Caucasians matched for gender and body mass index (BMI). This was influenced by degree of visceral adipose deposition and ectopic fat accumulation in k...
2022-10-12 | MTBLS5568 | MetaboLights
TranscriptomicsCardiac miRNA expression changes induced by prediabetes
The aim of the experiment was the analysis of key molecular changes with an unbiased, transcriptomics-based approach in a prediabetes model. Small RNA sequencing analysis was applied to explore the expression changes resulted high-fat chow (supplemented with 40% lard) diet for 21 weeks and a single ...
ORGANISM(S): Rattus norvegicus 
2020-04-24 | E-MTAB-8204 | biostudies-arrayexpress
GenomicsCardiac miRNA expression changes induced by prediabetes
Cardiac miRNA expression changes induced by prediabetes
PRJEB33812 | ENA
ProteomicsA Metabolite Triplet in Serum Improves the Diagnostic Accuracy of Prediabetes and Diabetes Screening
In this study, applying a novel knowledge-based, multi-stage discovery and validation strategy we scaled down from 108 diabetes–associated metabolites to a diagnostic metabolite triplet (Met-T) and it could improve the diagnostic accuracy of prediabetes and diabetes screening.
ORGANISM(S): Homo Sapiens 
2020-11-30 | PXD022801 |
Genomicsprediabetes mice
prediabetes mice Raw sequence reads
PRJNA1331485 | ENA
GenomicsLongitudinal multi-omics profiling of prediabetes
Longitudinal multi-omics profiling of prediabetes
PRJNA497500 | ENA
GenomicsLongitudinal multi-omics profiling of prediabetes
Longitudinal multi-omics profiling of prediabetes
PRJNA497499 | ENA
GenomicsSulforaphane reduces fasting blood glucose in prediabetes with differential effect based on pathophysiology and microbiome composition
Sulforaphane reduces fasting blood glucose in prediabetes
PRJEB77105 | ENA
GenomicsNicotinamide mononucleotide increases muscle insulin sensitivity in women with prediabetes
Nicotinamide mononucleotide increases muscle insulin sensitivity in women with prediabetes
PRJNA663592 | ENA
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