Preformed fibrils

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CHEBI:16135 (2)
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Pi-Methylhistidine (2)
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3-Hydroxyisovalerate (2)
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Lab affiliation

Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana 47907, United States (2)
Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana 47907, United States (1)
Dana Farber Cancer Institute, Boston, MA Harvard Medical School, Boston, MA (1)
Department of Neurology Institute for Cell Engineering Johns Hopkins University School of Medicine (1)
Center of Basic Science, Biomedical Research Foundation of the Academy of Athens, Athens, Greece (1)
Rush University Medical Center (1)
Mootha Lab Department of Molecular Biology Massachusetts General Hospital Boston, MA, USA (1)
Université du Québec à Montréal (UQAM) Département des Sciences Biologiques, SB-3435 Case postale 8888, succursale Centre-Ville Montréal (Québec) H3C 3P8 (1)

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Transcriptomic Profiling of Early Synucleinopathy in Rats Induced with Preformed Fibrils

PRJNA1031579 | ENA

Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia

PRJNA1163099 | ENA

Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia

To detect the microglial mRNA signature whilst phagocytosing alphasynuclein preformed fibrils (αSyn PFFs) with or without inflammatory stimulus, we treated the healthy control microglia with IFNγ (20ng/ml) 28h and αSyn PFFs (0.5µM) 4h

ORGANISM(S): Homo sapiens

2024-10-22 | GSE277636 | GEO

Single Molecule Fingerprinting Reveals Different Amplification Properties of α-Synuclein Oligomers and Preformed Fibrils in Seeding Assay.

Not available

S-EPMC8990999 | biostudies-literature

Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.

Not available

S-EPMC8304385 | biostudies-literature

Does alpha synuclein strain or GCase enzyme activity drive clinical aggression in GBA-PD?

Parkinson’s disease (PD) is a neurodegenerative disease characterized by progressive motor symptoms and alpha-synuclein (αsyn) aggregation in the nervous system. For unclear reasons, PD patients with certain GBA mutations (GBA-PD) have a more aggressive clinical progression. Two testable hypotheses ...

ORGANISM(S): Mus musculus (Mouse)

2024-02-22 | PXD045437 | Pride

Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils.

Not available

S-EPMC10199563 | biostudies-literature

α-Synuclein Preformed Fibrils Bind to β-Neurexins and Impair β-Neurexin-Mediated Presynaptic Organization.

Not available

S-EPMC10093570 | biostudies-literature

Observation of α-Synuclein Preformed Fibrils Interacting with SH-SY5Y Neuroblastoma Cell Membranes Using Scanning Ion Conductance Microscopy.

Not available

S-EPMC9782390 | biostudies-literature

Biochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (NMR assay)

Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...

2019-02-07 | MTBLS640 | MetaboLights

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