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MetabolomicsNeuroactive metabolites and bile acids are altered in extremely premature infants with brain injury

The gut microbiome has been associated with pathological neurophysiological evolvement in extremely premature infants suffering from brain injury. The exact underlying mechanism and its associated metabolic signatures in infants are not fully understood. To decipher metab...

2023-12-30 | MTBLS7560 | MetaboLights
TranscriptomicsEffect of Nrf2 deletion in postnatal lung development and BPD phenotype in newborn mice
Background: Nrf2 is an essential cytoprotective transcription factor. However, association of Nrf2 in organ development and neonatal disease is rarely examined. Hyperoxia exposure to newborn rodents generates pulmonary phenotypes which resemble bronchopulmonary dysplasia (BPD) of prematurity. Method...
ORGANISM(S): Mus musculus 
2012-05-24 | E-GEOD-29632 | biostudies-arrayexpress
TranscriptomicsThe DNA Methylomes of a Newborn and a Centenarian
Examination of two DNA methylomes at the most extreme points of their lives to see differences that might contribute to explain the aged phenotype We have performed Whole Genome Bisulfite Sequencing (WGBS) and methylation array technology of newborn and a centenarian samples to address the Epigeneti...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-31438 | biostudies-arrayexpress
UnknownOptimal Timing to Utilize Olfactory Stimulation with Maternal Breast Milk to Improve Oral Feeding Skills in the Premature Newborn.
Not available
S-EPMC10027347 | biostudies-literature
UnknownSurfactant proteins gene variants in premature newborn infants with severe respiratory distress syndrome.
Not available
S-EPMC5953905 | biostudies-literature
UnknownPrimary immunodeficiency testing in a Massachusetts tertiary care NICU: persistent challenges in the extremely premature population.
Not available
S-EPMC8287644 | biostudies-literature
TranscriptomicslncRNA expression profiles for preterm premature rupture of membrane (PPROM)
Investigation of lncRNA expression profile of PPROM Arraystar Human LncRNA Array v2.0 was applied to study 40 placentas.
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-50879 | biostudies-arrayexpress
ProteomicsMetaproteome of preterm infant gut microbiome
91 preterm infant gut metaproteomes measured in technical duplicate using an eleven salt pulse 2D-LC-MS/MS method. Samples represent 17 preterm infants over the first several weeks of life, of which 6 preterm infants eventually developed necrotizing enterocolitis.
ORGANISM(S): Microbiome 
MSV000086096 | MassIVE
TranscriptomicsKnockout of GPx4 gene in mouse keratinocyte
Comparative analysis of gene expression in cultured primary keratinocytes isolated from newborn control (K14-cre; GPx4fl/+) and knockout (K14-cre; GPx4fl/fl) mice. Selenoproteins are essential for skin function, as targeted abolition of selenoproteins in epidermal tissue results in newborn mice mani...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-34215 | biostudies-arrayexpress
TranscriptomicsKidney Stone Induces Developmental Stage-specific Alterations in Gene Expression
OBJECTIVES: Kidney stone diseases are common in premature infants, but the underlying molecular and cellular mechanisms are not fully defined. We carried out a prospective observational study using microarray analysis to identify factors that may be crucial for the initiation and progression of ston...
ORGANISM(S): Mus musculus 
2010-01-13 | E-GEOD-18160 | biostudies-arrayexpress
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