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ProteomicsStructural mechanisms of allosteric regulation in the human cis-prenyltransferase complex
Human cis-prenyltransferase (hcis-PT) synthesizes long-chain isoprenoids essential for N-linked protein glycosylation. This heteromeric complex comprises the catalytic subunit DHDDS and the regulatory Nogo-B receptor (NgBR). Although NgBR dramatically enhances DHDDS activity, the molecular basis for...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD063722 | Pride
Nogo-b receptor Allosteric regulation Dehydrodolichyl diphosphate synthase Cis-prenyltransferase Dhdds N-linked glycosylation Molecular dynamics simulations Hydrogen-deuterium exchange mass spectrometry Network analysis Ngbr 
ProteomicsStructural analysis of human cis-prenyltransferase
Isoprenoids are synthesized by the prenyltransferases superfamily, which is subdivided according to the product stereoisomerism and length. In short- and medium-chain isoprenoids, product length correlates with active site volume. However, enzymes synthesizing long-chain products and rubber synthase...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD031707 | Pride
Cis-prenyltransferase H/d exchange mass spectrometry Isoprenoid synthesis 
UnknownEngineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase.
Not available
S-EPMC8551067 | biostudies-literature
UnknownPrenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
Not available
S-EPMC4270290 | biostudies-literature
UnknownTransient Prenyltransferase-Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase.
Not available
S-EPMC9648990 | biostudies-literature
UnknownBiochemical characterization of a multiple prenyltransferase from Tolypocladium inflatum.
Not available
S-EPMC10965706 | biostudies-literature
UnknownStructure, catalysis, and inhibition mechanism of prenyltransferase.
Not available
S-EPMC7839719 | biostudies-literature
UnknownMolecular characterization of the cis-prenyltransferase of Giardia lamblia.
Not available
S-EPMC2900897 | biostudies-literature
UnknownIndole C6 Functionalization of Tryprostatin B Using Prenyltransferase CdpNPT.
Not available
S-EPMC7906295 | biostudies-literature
UnknownStructure and specificity of a permissive bacterial C-prenyltransferase.
Not available
S-EPMC5362326 | biostudies-literature
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