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MetabolomicsMetabolomics uncovers the dual effects of high-pressure and ultra-shear processing in juice
This study investigated the chemical changes in a blended fruit and vegetable juice induced by innovative food processing technologies - high-pressure processing (HPP; 400 MPa, 40oC) and ultra-shear technology (UST; 400 MPa, 40 and 72 °C) - in comparison to conventional thermal treatments at 40 and ...
2025-06-25 | MTBLS12637 | MetaboLights
MetabolomicsTranscriptional Shift and Metabolic Adaptations during Leishmania Quiescence Using Stationary Phase and Drug Pressure as Models

Microorganisms can adopt a quiescent physiological condition which acts as a survival strategy under unfavourable conditions. Quiescent cells are characterized by slow or non-proliferation and deep down-regulation of processes related to biosynthesis. Although quiescence has been described mostly...

2022-02-23 | MTBLS4046 | MetaboLights
MetabolomicsMulti-Omic Insights into the Cellular Response of Phaeodactylum Tricornutum (Bacillariophyta) Strains under Grazing Pressure

BACKGROUND/AIMS: Phaeodactylum tricornutum, a model organism of diatoms, plays a crucial role in Earth's primary productivity. Investigating its cellular response to grazing pressure is highly significant for the marine ecological environment. Furthermore, the integration of mult...

2023-12-29 | MTBLS8485 | MetaboLights
MetabolomicsACAD8 deficiency promotes pathological cardiac hypertrophy in response to pressure overload by regulating histone isobutyrylation
Branched-chain amino acids play critical roles in cardiac physiology and diseases. Genetic deficiency in the valine catabolic enzyme ACAD8 is clinically associated with isobutyryl-CoA deregulation and cardiomyopathy in humans. To explore the mechanism underlying cardiac pathological hypertrophy in A...
2026-04-15 | MTBLS14207 | MetaboLights
TranscriptomicsThe regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure.
Following parenchymal loss, the liver regenerates restoring normal mass and metabolic function. Prevailing theories on triggering events leading to regeneration include humoral, metabolic and flow-mediated mechanisms, the latter emphasizing the importance of shear stress mediated nitric oxide (NO) r...
ORGANISM(S): Sus scrofa 
2008-01-14 | E-GEOD-6860 | biostudies-arrayexpress
TranscriptomicsDeletion of Rictor in brain and fat alters peripheral clock gene expression and increases blood pressure
The mammalian target of rapamycin complex 2 (mTORC2) contains the essential protein RICTOR and is activated by growth factors. mTORC2 in adipose tissue contributes to regulating glucose and lipid metabolism. In the perivascular adipose tissue (PVAT) mTORC2 ensures normal vascular reactivity by contr...
ORGANISM(S): Mus musculus 
2015-07-05 | E-GEOD-67077 | biostudies-arrayexpress
MetabolomicsInvestigating Eicosanoids Implications on the Blood Pressure Response to Thiazide Diuretics
Not available
ORGANISM(S): Homo sapiens 
ST000919 | MetabolomicsWorkbench
TranscriptomicsGene expression profiling of a pressure-tolerant Listeria monocytogenes Scott A ctsR deletion mutant
Transcriptional profling of a Listeria monocytogenes under pressure comparing ctsR mutant and wild type one condition (pressure 450 Moa, 3min) experiment, mutant vs. wild type, 2 biological replicates, two technical replicates
ORGANISM(S): Listeria monocytogenes 
2011-06-10 | E-GEOD-22819 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human optic nerve head (ONH) astrocytes exposed to either 60 mm Hg hydrostatic pressure (HP) or control ambient pressure (CP) to identify HP-responsive genes
Gene expression in human optic nerve head (ONH) astrocytes exposed to either 60 mm Hg hydrostatic pressure (HP) or control ambient pressure (CP) was compared using Affymetrix GeneChip microarrays to identify HP-responsive genes. Primary ONH astrocytes from two male Caucasian donors (passage 4) were ...
ORGANISM(S): Homo sapiens 
2007-09-25 | E-GEOD-758 | biostudies-arrayexpress
TranscriptomicsDetection of potential neuroprotective changes at the molecular, anatomical and physiological level in identified human pyramidal cells in response to brain edema and increased intracranial pressure.
Here we show a workflow combining single cell electrophysiology, anatomy and molecular biology in neurons identified in situ to assess mRNA expression at single molecule precision and corresponding functional changes in response to edema and increased intracranial pressure. This combination of metho...
ORGANISM(S): Homo sapiens 
2016-10-27 | E-MTAB-3678 | biostudies-arrayexpress
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