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MetabolomicsA metabolic dependency of EBV can be targeted to hinder B cell transformation

Following infection of B cells, Epstein Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates NAD de novo bios...

2024-04-29 | MTBLS2243 | MetaboLights
MetabolomicsOverexpression of Brassica napus COMT1 in Arabidopsis heightens UV-B-mediated resistance to Plutella xylostella herbivory

UV-B radiation regulates numerous morphogenic, biochemical and physiological responses in plants, and can stimulate some responses typically associated with other abiotic and biotic stimuli, including invertebrate herbivory. Removal of UV-B from the growing environment of various plant species ha...

2023-08-14 | MTBLS8236 | MetaboLights
TranscriptomicsA distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection
This study included single-cell RNA-seq and scATAC-seq data from PBMCs from 12 COVID-19 individuals at acute infection.
ORGANISM(S): Homo sapiens 
2026-08-28 | E-MTAB-13745 | biostudies-arrayexpress
TranscriptomicsExpression data from CXCR4pos (centroblast) and CXCR4neg (centrocyte) Human Germinal Center B cells
Functional discrimination between normal centroblast and centrocyte obtained from human inflamed tonsils after cell sorting. We used microarrays to detail the segregation between these two B cell subsets Flow cytometry analysis was done on human germinal center B cells and cell subsets, i.e. CXCR4po...
ORGANISM(S): Homo sapiens 
2009-06-04 | E-GEOD-15271 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mature, naive B cells to investigate how the PTPN22 autoimmune susceptibility gene affects the removal of human developing autoreactive B cells.
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene segregates with most autoimmune diseases; its risk allele encodes overactive PTPN22 phosphatases that alter B cell receptor (BCR) signaling potentially involved in the regulation of central B cell tolerance. To assess whether PTPN22 ris...
ORGANISM(S): Homo sapiens 
2010-10-16 | E-GEOD-24736 | biostudies-arrayexpress
ProteomicsLabel-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line
Hepatitis B virus (HBV) infection is a major health problem worldwide. Recent evidence suggests that various viruses can manipulate the infection process by secretion of specific viral and cellular components into exosomes, small nanometer-sized (30-150 nm) vesicles secreted from various cells. Howe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080718 | MassIVE
MetabolomicsSeed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit
Rice (Oryza sativa L.) is a candidate crop for production of plant-based vaccines by genetic engineering technologies. MucoRice-CTB has been developed as a rice-seed-based vaccine against cholera by transgenic expression of modified cholera toxin B-subunit (CTB) under the RNA interference (RNAi)-med...
2017-08-30 | MTBLS437 | MetaboLights
ProteomicsGeneration of aggregates of alpha-lactalbumin by UV-B light exposure
Whey proteins are widely used as ingredients in the form of aggregates to obtain certain functionalities in food applications. The aim of this study was to understand how UV illumination generates aggregates of alpha-lactalbumin (a-LA) as an alternative to heat treatments traditionally used for indu...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2019-12-16 | MSV000084695 | MassIVE
TranscriptomicsRNA-seq data to map the AtsR regulon in B. cenocepacia
In this study, we embark on a journey to unravel the profound impact of atsR (Adherence and T6SS Regulator) gene deletion on the transcriptome and the proteome of B. cenocepacia K56-2 upon growth in synthetic CF medium (SCFM), the most in-vivo-like culturing medium. Our insights, derived from RNA-se...
ORGANISM(S): Burkholderia cenocepacia 
2026-03-31 | E-MTAB-13688 | biostudies-arrayexpress
UnknownDoes price disclosure in pharmaceutical advertising result in price transparency? Evidence from a randomized experiment.
Not available
S-EPMC9526226 | biostudies-literature
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