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ProteomicsNatural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors.
Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive CNS-tumors of infancy and early childhood. Hallmark is the surprisingly simple genomics with a truncating mutation in the SMARCB1 gene as the oncogenic driver. Nevertheless, AT/RTs are infiltrated by immune cells and even clonally expan...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD033935 | Pride
Human Primary at/rt tumors Hla-i and hla-ii 
ProteomicsPrimary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors
Atypical teratoid/rhabdoid tumor (AT/RT) is the most common malignant brain tumor in infants and is characterized by loss of nuclear SMARCB1 protein expression. Recent studies show that AT/RTs comprise three molecular subgroups with epigenetic differences, including distinct expression patterns of g...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD027211 | Pride
Atypical teratoid/rhabdoid tumor Targeted therapy Stat1/dr5 signaling Primary cilia 
TranscriptomicsIntegrated genomics identifies a new AT/RT-like yet INI1-positive brain tumor subtype among primary pediatric embryonal tumors
Pediatric embryonal brain tumor (PEBT), which includes medulloblastoma (MB), primitive neuroectodermal tumor (PNET) and atypical teratoid/rhabdoid tumor (AT/RT), is the second most prevalent pediatric tumor type among brain tumors of childhood. AT/RT is highly malignant and is often misdiagnosed as ...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-65132 | biostudies-arrayexpress
TranscriptomicsIntegrated genomics identifies a new AT/RT-like yet INI1-positive brain tumor subtype among primary pediatric embryonal tumors
Pediatric embryonal brain tumor (PEBT), which includes medulloblastoma (MB), primitive neuroectodermal tumor (PNET) and atypical teratoid/rhabdoid tumor (AT/RT), is the second most prevalent pediatric tumor type among brain tumors of childhood. AT/RT is highly malignant and is often misdiagnosed as ...
ORGANISM(S): Homo sapiens 
2015-01-22 | GSE65132 | GEO
TranscriptomicsPediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes
Rhabdoid tumors (RTs) are aggressive tumors of early childhood that occur most often in brain (AT/RTs) or kidney (KRTs). Regardless of location, they are characterized by loss of functional SMARCB1 protein, a component of the SWI/SNF chromatin remodeling complex. The aim of this study was to determi...
ORGANISM(S): Homo sapiens 
2013-01-21 | E-GEOD-35493 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of tumor cells from the cerebrospinal fluid and matched primary tumors from metastatic breast cancer patients with leptomeningeal disease
We purified tumor cells in the CSF (M-bM-^@M-^\CSFTCM-bM-^@M-^]) from 15 metastatic breast cancer patients diagnosed with leptomeningeal disease using a two-step method involving immunomagnetic enrichment and fluorescence-activated cell sorting (IE/FACS). Magnetic beads coated with mAb to the epithe...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-46068 | biostudies-arrayexpress
GenomicsRelapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics [DNA methylation]
Relapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics [DNA methylation]
PRJNA948028 | ENA
GenomicsPrimary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors
Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors
PRJNA744517 | ENA
UnknownIntegrated genomics has identified a new AT/RT-like yet INI1-positive brain tumor subtype among primary pediatric embryonal tumors.
Not available
S-EPMC4480900 | biostudies-literature
GenomicsRelapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics [RNA-seq]
Relapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics [RNA-seq]
PRJNA948039 | ENA
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