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TranscriptomicsExpression data from renal cysts of autosomal dominant polycystic kidney disease (ADPKD) patients
To elucidate the molecular pathways that modulate renal cyst growth in autosomal dominant polycystic kidney disease (ADPKD) Keywords: Disease state analysis We performed global gene profiling on renal cysts of different size (small cysts: less than 1 ml, n=5; medium cysts: between 10-25 ml, n=5; lar...
ORGANISM(S): Homo sapiens 
2009-08-14 | E-GEOD-7869 | biostudies-arrayexpress
TranscriptomicsExpression data from renal primary epithelial cells
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in the ADPKD genes PKD1 and PKD2 account for nearly all the cases of ADPKD. Increased cell prolif...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-11500 | biostudies-arrayexpress
TranscriptomicsDigital gene expression profiling of the Phytophthora sojae transcriptome
This experiment contains Phytophthora sojae samples and RNA-seq data from experiment E-GEOD-29561 (https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-29651/) to understand gene expression during the P. sojae life cycle. The transcriptome of the oomycete plant pathogen Phytophthora sojae was profi...
ORGANISM(S): Phytophthora sojae 
2011-09-01 | E-MTAB-4039 | biostudies-arrayexpress
TranscriptomicsDigital gene expression profiling of the Phytophthora sojae transcriptome
The transcriptome of the oomycete plant pathogen Phytophthora sojae was profiled at 10 different developmental and infection stages based on a 3'-tag digital gene expression (DGE) protocol. More than 90 million clean sequence tags were generated and compared to the P. sojae genome and its 19,027 pre...
ORGANISM(S): Glycine max 
2011-09-01 | E-GEOD-29651 | biostudies-arrayexpress
TranscriptomicsChromosomal abnormalities in hepatic cysts point to novel polycystic liver disease genes
Autosomal dominant polycystic liver disease (ADPLD) is caused by mutations in PRKCSH, SEC63, and LRP5, while autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1, and PKD2. Liver cyst development in these disorders is explained by somatic loss-of-heterozygosity (LOH) o...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-78808 | biostudies-arrayexpress
TranscriptomicsGene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease
Nasu-Hakola disease (NHD), also designated polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare autosomal recessive disorder characterized by progressive presenile dementia and formation of multifocal bone cysts, caused by a loss-of-function mutation of DAP...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-33500 | biostudies-arrayexpress
TranscriptomicsThe role of HIF in FH-associated renal neoplasia
Fumarate hydratase (FH) mutations predispose to renal cysts cancer. These cancers overexpress hypoxia-inducible factor-alpha (Hif-1a). We have generated a conditional Fh1 (mouse FH) knockout mice that develop renal cysts and overexpress Hif-1a. In order to identify the contribution of Hif-1a to cyst...
ORGANISM(S): Mus musculus 
2011-10-23 | E-GEOD-29988 | biostudies-arrayexpress
UnknownDistinct patterns of primary and motile cilia in Rathke's cleft cysts and craniopharyngioma subtypes.
Not available
S-EPMC5442446 | biostudies-literature
TranscriptomicsGene expression changes between primary mesothelioma tumour cells and commercially available cell lines, compared to normal primary mesothelial cells
Malignant mesothelioma (MM) is an aggressive, fatal tumour strongly associated with asbestos exposure. There is an urgent need to improve MM patient outcomes and this requires functionally validated pre-clinical models. Mesothelioma-derived cell lines provide an essential and robust tool widely used...
ORGANISM(S): Homo sapiens 
2018-02-01 | E-MTAB-6351 | biostudies-arrayexpress
GenomicsTranscriptomic analysis of renal cell carcinoma and cysts in a patient affected by von Hippel Lindau disease
Transcriptomic analysis of renal cell carcinoma and cysts in a patient affected by von Hippel Lindau disease
PRJNA1070592 | ENA
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