Primary fibroblasts

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Organisms

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Organisms

Homo sapiens (1002)
Mus musculus (496)
Rattus norvegicus (21)
Gallus gallus (12)
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Oryctolagus cuniculus (1)
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Macaca mulatta (1)
Capra hircus (1)

Repository

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Tissue

Fibroblast (125)
Cell culture (85)
Primary cell (25)
Skin (22)
Heart (13)
Epithelial cell (8)
Umbilical vein (6)
Breast (6)
Endothelial cell of umbilical vein (6)
Brain (5)
Stem cell (5)
Embryo (5)
Lung (5)
Permanent cell line cell (4)
Blood cell (4)
Embryonic fibroblast (3)
Cell suspension culture (3)
T cell (3)
Epithelium of pancreatic duct (2)
Mesothelial cell of pleura (2)
Myofibroblast cell (2)
Fibroblast of dermis (2)
Fibroblast of lung (2)
Pleural mesothelium (2)
Melanocyte (2)
Embryonic stem cell (2)
Early embryonic cell (2)
Kidney (2)
Liver (2)
Fibroblast cells (1)

Disease

Normal (15)
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Not Available (4)
Glioblastoma multiforme (3)
Adenocarcinoma (3)
Rheumatoid arthritis (3)
Cancer (2)
Primary lateral sclerosis (1)
Upper Motor Neuron Disease (1)
Sporadic amyotrophic lateral sclerosis (1)
Myelodysplasia (1)
Gastric carcinoma (1)
Mucopolysaccharidosis type 6 (1)
Perilobar nephrogenic rest (1)
CUP (1)
Spindle cell tumor (1)
Neuroblastoma-undifferentiated (1)
Mitochondrial complex I deficiency (1)
Hutchinson-Gilford Progeria Syndrome (1)
Chronic pancreatitis (1)
AIDS-KS, HIV+, nodular (late) stage (1)
Epidermoid carcinoma (1)
Basal cell carcinoma, Gorlin-Goltz syndrome (1)
Alpha-1 antitrypsin deficiency (1)
Short stature-onychodysplasia-facial dysmorphism-hypotrichosis syndrome (1)
Glioblastoma (1)
Nodal peripheral T-cell Lymphoma (1)
Control (1)

Technology Type

Mass Spectrometry (236)
Shotgun proteomics (153)
Bottom-up proteomics (30)
Affinity purification coupled with mass spectrometry proteomics (24)
Mass spectrometry (17)
Data-independent acquisition (15)
Gel-based experiment (15)
Data-dependent acquisition (14)
Top-down proteomics (10)
SWATH MS (9)
DiaPASEF (6)
Mass spectrometry assay (5)
Illumina HiSeq 2000 (4)
NMR spectroscopy (4)
All-ion fragmentation (2)
ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 2000, ILLUMINA, Illumina HiSeq 2500 (1)
Ilumina HumanHap550-2v3_B-Beadstudio (1)
ESI (1)
Mass spectrometry imaging (1)
SRM/MRM (1)

Instrument Platform

Illumina NovaSeq 6000 (58)
Illumina HiSeq 2500 (45)
Illumina HiSeq 4000 (39)
NextSeq 500 (34)
Illumina HiSeq 2000 (20)
NextSeq 550 (11)
NextSeq 2000 (8)
Illumina NovaSeq X (7)
Illumina HiSeq 1500 (7)
DNBSEQ-G400 (4)
Qubit 4.0 Fluorometer/ Agilen 5300 Fragment Analyzer (3)
GenePix 4000B [Axon Instruments] (3)
NA (3)
Fluidigm C1 (2)
Illumina BeadArray reader (2)
Affymetrix GeneChip Scanner 3000 7G (2)
G2565AA DNA microarray scanner [Agilent] (2)
Illumina Genome Analyzer IIx (2)
G2565BA DNA microarray scanner [Agilent] (2)
Illumina Genome Analyzer II (2)
Axon GenePix 4000B scanning hardware (2)
NextSeq 550 (Illumina). (1)
Hamamatsu Nanozoomer S60 (1)
Qiagen RNEasy Mini ki (1)
BD FACSAriaIIu cell sorter (1)
10x Genomics Chromium Controller, PCR thermocycler, Agilent 2100 Bioanalyzer with High Sensitivity DNA chip (for quality control) (1)
Water bath (for enzymatic dissociation), cell strainer (70-μm), benchtop centrifuge, automated cell counter/hemocytometer, biological safety cabinet (1)
Sterile surgical instrument set (scalpels, tissue forceps, dissection scissors), animal operating table, biological safety cabinet (1)
Poly-T oligo-attached magnetic beads (1)
Faxitron 43855-D irradiator (1)

Publication Date

2014 (343)
2013 (323)
2010 (316)
2011 (263)
2012 (248)
2016 (247)
2015 (218)
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2024 (156)
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2021 (135)
2008 (124)
2022 (122)
2020 (121)
2009 (120)
2018 (110)
2019 (90)
2017 (90)
2007 (59)
2005 (35)
2006 (32)
2004 (11)
2003 (5)
2027 (1)

UNIPROT ID/AC

CRLD1_HUMAN (6)
TMM47_HUMAN (6)
ERG28_HUMAN (6)
ALKL2_HUMAN (6)
CAD24_HUMAN (6)
SOX8_HUMAN (6)
APLD1_HUMAN (6)
TGFB2_HUMAN (6)
KCC1B_HUMAN (6)
NU2M_HUMAN (6)
RGPD5_HUMAN (6)
C1QT1_HUMAN (6)
DAND5_HUMAN (6)
IL17B_HUMAN (6)
V9GYH6_HUMAN (6)
GSTT2_HUMAN (6)
H2A2A_HUMAN (6)
CP096_HUMAN (6)
U2AF1_HUMAN (6)
PGGHG_HUMAN (6)
RM51_HUMAN (6)
RM30_HUMAN (6)
PHX2B_HUMAN (6)
GATC_HUMAN (6)
FITM1_HUMAN (6)
COE2_HUMAN (6)
P24941 (1)
P38936 (1)
P24864 (1)
P04637 (1)

CHEBI ID

CHEBI:15741 (10)
CHEBI:16704 (10)
CHEBI:16027 (10)
CHEBI:17596 (10)
CHEBI:16856 (9)
CHEBI:15891 (9)
CHEBI:18012 (9)
CHEBI:17368 (9)
CHEBI:17202 (8)
CHEBI:17562 (8)
CHEBI:16870 (8)
CHEBI:16977 (8)
CHEBI:15428 (8)
CHEBI:17268 (8)
CHEBI:16865 (8)
CHEBI:16335 (8)
CHEBI:7916 (8)
CHEBI:32816 (8)
CHEBI:16761 (8)
CHEBI:30915 (8)
CHEBI:30769 (8)
CHEBI:18132 (7)
CHEBI:18237 (7)
CHEBI:22660 (7)
CHEBI:18186 (7)
CHEBI:16695 (7)
CHEBI:16708 (7)
CHEBI:17361 (7)
CHEBI:17568 (7)
CHEBI:29016 (7)

Metabolite Name

IMP (8)
AMP (8)
ADP (8)
Creatinine (8)
UMP (7)
Taurine (7)
Adenine (7)
Creatine (7)
ATP (6)
L-Alanine (6)
L-Proline (6)
Choline (6)
Uridine (6)
L-Leucine (6)
Inosine (6)
Hypoxanthine (6)
Uridine (5)
NAD+ (5)
Uracil (5)
CMP (5)
Arginine (5)
Lysine (5)
Adenosine (5)
NADH (5)
L-Glutamine (5)
Fumarate (5)
L-Serine (5)
Xanthine (5)
Guanosine (5)
L-Phenylalanine (5)

First Public Date

2014 (309)
2026 (228)
2025 (225)
2024 (196)
2023 (155)
2021 (121)
2020 (117)
2022 (114)
2019 (94)
2018 (73)
2017 (63)
2016 (51)
2015 (40)
2013 (26)

Modelling Approach

Ordinary differential equation model (2)

Lab affiliation

University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (21)
Department of Biology, University of Rochester, NY, USA (3)
Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, CA 92037 (3)
EDyP (3)
Department of Cell & Developmental Biology, University of California, San Diego, CA 92093, USA. (3)
Dr. Jörn Dengjel Department of Biology, University of Fribourg Chemin du Musée 10, 1700 Fribourg, Switzerland T +41 26 300 8631 E joern.dengjel@unifr.ch (2)
Proteomics program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark (2)
National Heart and Lung Institute, Imperial College London, United Kingdom (2)
Department of Molecular Biology, Princeton University, USA (2)
Institut Pasteur 25 Rue du Docteur Roux Paris 75015 (2)
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, United States (2)
IRCCS Istituto G Gaslini (2)
Proteomics Center, Erasmus MC (2)
Manchester Cell-Matrix Centre, Division of Molecular and Cellular Function, FBMH, University of Manchester (1)
Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK (1)
Mitochondrial biology group, Institut Pasteur, Paris (1)
Speaker of the Omics Center Head of Research Unit "Functional Proteomics and Metabolomic Pathways" Medical University Graz ZMF, Stiftingtalstrasse 24 8010 Graz Austria (1)
Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. Otto-Hahn-Straße 6b 44227 Dortmund, Germany P: +49 (0)2 31.13 92-100 F: +49 (0)2 31.13 92-200 albert.sickmann@isas.de www.isas.de twitter.com/isas_Leibniz (1)
Monash University Molecular Biology and Biochemistry (1)
Monash Partners Comprehensive Cancer Consortium, Monash Biomedicine Discovery Institute Cancer Program, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia (1)
Animal Clinical Pathology, College of Animal Science and Veterinary Medicine, Shandong Agricultural University,Shandong Province, China (1)
Department of Pathology, Medical University of Vienna, Austria (1)
Department of Biomedical Science and Technology, Kyung Hee Medical Science Research Institute, Kyung Hee University, Seoul, South Korea (1)
Radboud University Nijmegen, The Netherlands (1)
Stanford University School of Medicine 279 Campus Drive Stanford, CA 94305-5323 (1)
Univ Rennes, CNRS, Inserm, Biosit UAR 3480 US_S 018, Protim Core Facility, F-35000 Rennes, France (1)
Director, Proteomics and Lipidomics Core Maine Medical Center Research Institute Scarborough, ME USA (1)
Laboratório Especial de Toxinologia Aplicada, Instituto Butantan,Av. Vital Brasil 1500, 05503-000, São Paulo, Brazil. (1)
Animal Cell Technology Unit, iBET - Instituto de Biologia Experimental e Tecnológica (1)
Max Planck Institute of Immunobiology and Epigenetics Freiburg, Germany (1)

IsPrivate

False (2)

Classification

protozoa (2)
bacteria (2)
viruses (1)

Modification

4x(2)H labeled dimethylated L-lysine (1)
4x(15)N labeled L-arginine (1)
N6-dimethyl-L-lysine (1)

Study type

Transcription profiling by array (1326)
RNA-seq of coding RNA (284)
ChIP-seq (187)
RNA-seq of coding RNA from single cells (57)
Methylation profiling by array (55)
Unknown experiment type (41)
Comparative genomic hybridization by array (40)
Other (33)
ChIP-chip by tiling array (29)
Methylation profiling by high throughput sequencing (26)
RNA-seq of non coding RNA (22)
Genotyping by array (18)
ChIP-chip by array (11)
Transcription profiling by RT-PCR (11)
Cell line - High-throughput sequencing (9)
Transcription profiling by SAGE (8)
RNA-seq of total RNA (7)
ATAC-seq (6)
MicroRNA profiling by array (6)
Human - High-throughput sequencing (5)
Animal - High-throughput sequencing (5)
Baseline (4)
Transcription profiling by tiling array (4)
DNA-seq (4)
Hi-C (3)
Animal - Single-cell sequencing (2)
Human - Single-cell sequencing (2)
High-throughput sequencing (2)
RNAi profiling by array (2)
MicroRNA profiling by high throughput sequencing (2)

Release Date

2022 (478)
2025 (474)
2014 (464)
2023 (452)
2021 (420)
2013 (413)
2016 (397)
2020 (384)
2024 (379)
2010 (375)
2015 (374)
2012 (333)
2011 (326)
2019 (314)
2018 (304)
2017 (270)
2008 (173)
2009 (169)
2026 (85)
2007 (77)
2006 (65)
2005 (55)
2004 (21)
2003 (16)
2000 (11)
2001 (10)
1999 (7)
1998 (7)
2002 (6)
1997 (2)

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LC-MS untargeted lipidomics of primary human fibroblasts

Not available

ORGANISM(S): Homo sapiens

ST001691 | MetabolomicsWorkbench

Selective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts

INTRODUCTION: A decline in mitochondrial function represents a key factor of a large number of inborn errors of metabolism, which lead to an extremely heterogeneous group of disorders.

OBJECTIVES: To gain insight into the biochemical consequences of mitocho...

2021-10-06 | MTBLS761 | MetaboLights

Proteome profiling of breast cancer biopsies reveals a wound healing signature of cancer-associated fibroblasts - primary mammary fibroblasts treated with IL1-beta

Breast cancer is still the most common type of cancer in women; an important role in carcinogenesis is actually attributed to cancer-associated fibroblasts. In this study we investigated whether it is possible to assess the functional state of cancer-associated fibroblasts through tumor tissue prote...