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MetabolomicsResveratrol metabolism in HepG2 (human hepatocytes), HaCaT (human keratinocytes), and C2C12 (mouse myoblasts)
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
MTBLS127 | MetaboLights
MetabolomicsLipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress
Liver steatosis can be induced by fasting or high-fat diet. We investigated by lipidomic analysis whether such metabolic states are reflected in the lipidome of hepatocyte lipid droplets (LDs) from mice fed normal chow diet (FED), fasted (FAS), or fed a high-fat diet (HFD). LC-MS/MS at levels of lip...
2014-08-19 | MTBLS26 | MetaboLights
MetabolomicsInhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control - LC-MS/MS data

The global type 2 diabetes epidemic is a major health crisis and there is a critical need for innovative strategies to fight it. Although the microbiome plays important roles in the onset of insulin resistance (IR) and low-grade inflammation, the microbial compounds regulating these phenomena rem...

2025-10-20 | MTBLS12975 | MetaboLights
ProteomicsMyristic acid induces proteomic changes in primary murine hepatocytes
Myristic acid, the 14-carbon saturated fatty acid (C14:0), is usually associated with negative consequences for human health, and in particular its consumption is correlated to an increased cardiovascular disease risk. Since it is a little abundant into the cells, its specific properties and functio...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-01 | PXD009017 | Pride
Mouse Primary murine hepatocytes Myristic acid Lc-ms/ms 
ProteomicsMouse hepatocyte conditioned media LC-MS/MS.
Hepatocyte caspase-8 is elevated in MASH and promotes fibrosis independently of apoptosis changes. To investigate how hepatocyte caspase-8 might drive liver fibrosis progression in MASH, we focused on activated hepatic stellate cells (HSCs), which are the primary source of collagen-producing myofibr...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-09 | PXD057540 | Pride
Aml12 Hepatocyte Conditioned media Lc-ms/ms 
MetabolomicsSpaceM reveals metabolic states of single cells

A growing appreciation of the importance of cellular metabolism and revelations concerning the extent of cell-cell heterogeneity demand metabolic characterization of individual cells. We present SpaceM, an open-source method for in situ single-cell metabolomics that detects >100 metabolites fr...

2021-05-11 | MTBLS78 | MetaboLights
ProteomicsProteomics of primary hepatocytes from hepatocyte-specific PRR-deficient mice
This dataset contains mass spectrometry-based proteomic profiling of primary hepatocytes isolated from wild-type and hepatocyte-specific PRR-deficient mice under normal chow diet conditions. The study was designed to investigate proteomic alterations associated with hepatocyte PRR deficiency.
ORGANISM(S): Mus musculus (Mouse) 
2026-08-28 | PXD078397 | Pride
Prr Proteomics Atp6ap2 Hepatocyte Primary hepatocyte Mouse 
ProteomicsListeria infection in hepatocytes
Listeria monocytogenes causes severe foodborne illness in pregnant women and immunocompromised individuals. After the intestinal phase of infection, the liver plays a central role in the clearance of this pathogen through its important functions in immunity. However, recent evidence suggests that su...
ORGANISM(S): Listeria monocytogenes EGD 
2021-11-02 | PXD027154 | Pride
Hepatocytes Listerai monocytogenes Lc-ms/ms 
ProteomicsEffects of VLK knockout on the proteome of primary mouse hepatocytes
In the project « VLK in liver protection », we analyzed conditioned medium and whole cell lysate of Y/A/C-treated hepatocytes isolated from wildtype (WT) and VLK knockout (KO) mice, three biological replicates each.
ORGANISM(S): Mus musculus (Mouse) 
2022-03-24 | PXD031378 | Pride
Mouse Liver Hepatocyte Lc-ms/ms 
ProteomicsPhosphoproteomics analysis reveals changes in primary hepatocytes following Wdr6 knockout
WDR6 was a scaffolding/ regulatory protein that interacts with diverse signaling molecules. Our findings showed that WDR6 might be involved in post-translational modifications (PTMs). Then we performed transcriptomic analysis of primary hepatocytes from WDR6-WKO and control mice.
ORGANISM(S): Mus musculus (Mouse) 
2023-09-22 | PXD034542 | Pride
Phosphoproteomics Mice Primary hepatocytes 
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