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TranscriptomicsSTAT1 independent control of a neurotropic measles virus challenge in primary neurons and infected mice
The objective of this study was to compare the ability of mice that lack STAT1 to resolve a neurotropic viral challenge, and to assess the ability of neurons obtained from these mice to be effectively cleared of virus by interferon gamma For the array, primary neurons were isolated from embryonic mi...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-33057 | biostudies-arrayexpress
ProteomicsDeep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics
The fatal neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are the most common motoneuron disease and genetic cause of infant death, respectively. Various in vitro model systems have been established to investigate motoneuron disease mechanisms - in p...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-08 | MSV000084939 | MassIVE
TranscriptomicsPathways Disrupted in Human ALS Motor Neurons Identified Through Genetic Correction of Mutant SOD1
Although many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron biology and whether they converge on common pathways to cause neural degeneration. Here, we have combined reprogramming...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-54409 | biostudies-arrayexpress
GenomicsMus musculus strain:primary neurons
Mus musculus strain:primary neurons Genome sequencing
PRJNA705847 | ENA
TranscriptomicsRNA-seq of human and mouse stem-cell derived neurons and mouse primary cortical neurons after KCl-induced membrane depolarization against controls.
This experiment comprises RNA-seq data used to study evolutionary differences between humans and mice in neuronal activity-dependent transcriptional responses. Activity-dependent transcriptional responses in developing human stem cell-derived cortical neurons were compared with those induced in deve...
ORGANISM(S): Mus musculus 
2017-02-16 | E-MTAB-5489 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of severe spinal muscular atrophy mouse embryonic stem cell-derived motor neurons
Proximal spinal muscular atrophy (SMA) is an early onset, autosomal recessive motor neuron disease caused by loss of or mutation in SMN1 (survival motor neuron 1). Despite understanding the genetic basis underlying this disease, it is still not known why motor neurons (MNs) are selectively affected ...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-56284 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans embryonic motor neurons.
Background: Differential gene expression specifies the highly diverse cell types that constitute the nervous system. With its sequenced genome and simple, well-defined neuroanatomy, the nematode C. elegans is a useful model system in which to correlate gene expression with neuron identity. The UNC-4...
ORGANISM(S): Caenorhabditis elegans 
2008-06-16 | E-GEOD-8159 | biostudies-arrayexpress
ProteomicsPhactr1/PP1 phosphatase substrates in mouse primary neurons
Neurons express Phactr1 at high level (Allen et al., 2004), and Phactr1 mutations are associated with morphological and functional developmental defects in cortical neurons (Hamada et al., 2018). To identify targets of the Phactr1/PP1 phosphatase holoenzyme, we cultured hippocampal and cortical neur...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-28 | PXD019882 | Pride
Neurons Phosphatase Mouse Phactr1 
ProteomicsEffects of ALS-associated tRNA-derived stress-induced RNA on the transcriptomic and proteomic profile of primary neurons in vitro
LtRNA-derived stress-induced RNAs (tiRNAs) are a new class of small non-coding RNA that have emerged as important regulators of cellular stress responses. tiRNAs are derived from specific tRNA cleavage by the stress-induced ribonuclease angiogenin (ANG). Loss-of-function mutations in the ANG gene ar...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-28 | PXD046961 | Pride
Transcriptome Proteome Als Rna Neurons. 
TranscriptomicsDCDC2 overexpression in rat primary hippocampal neurons
Transcriptome profiling of rat primary hippocampal neurons when the dyslexia candidate gene DCDC2 is overexpressed using transient transfections.

Additional processed data files and their associated custom CDF are available on the FTP site for this experiment.
ORGANISM(S): Rattus norvegicus 
2011-03-01 | E-MTAB-518 | biostudies-arrayexpress
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