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ProteomicsPhactr1/PP1 phosphatase substrates in mouse primary neurons
Neurons express Phactr1 at high level (Allen et al., 2004), and Phactr1 mutations are associated with morphological and functional developmental defects in cortical neurons (Hamada et al., 2018). To identify targets of the Phactr1/PP1 phosphatase holoenzyme, we cultured hippocampal and cortical neur...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-28 | PXD019882 | Pride
Neurons Phosphatase Mouse Phactr1 
ProteomicsPhactr1/PP1 phosphatase substrates in mouse NIH3T3 fibroblasts
It was previously shown that expression of an activated Phactr1 mutant (Phactr1XXX) that constitutively forms the Phactr1/PP1 phosphatase holoenzyme, induces F-actin rearrangements in NIH3T3 fibroblasts. Expression of the Phactr1 PP1-binding domain (C-terminal) alone is also sufficient to induce suc...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-28 | PXD019977 | Pride
Phosphatase Mouse Phactr1 Fibroblasts 
ProteomicsPHACTR1, a coronary artery disease risk gene, drives endothelial dysfunction
Recent genome-wide association studies have identified PHACTR1 as a critical risk gene associated with polyvascular diseases. However, it remains elusive how PHACTR1 is involved in endothelial dysfunction. Here, we show that PHACTR1 triggers endothelial inflammation by activating NF-κB and disrupts ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-16 | PXD034213 | Pride
Endothelial dysfunction  inflammation  phactr1  nitric oxide  innate immunity  coronary artery disease 
TranscriptomicsRNA-seq of PHACTR1 knockdown and overexpression in HT1080 stable cell lines
The PHACTR1 gene to a range of vascular and neurological diseases, underscoring its pivotal role in biology. As part of a larger multi-omics study, we performed bulk RNA-seq on stable HT1080 cell lines with overexpression or knockdown of PHACTR1, comparing them to scrambled control cells, to underst...
ORGANISM(S): Homo sapiens 
2025-12-22 | E-MTAB-15583 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of Phactr1 overexpression in human endothelial cells
Phactr-1 is an actin and protein phosphatase 1 (PP1) binding protein which is reported to be highly expressed in brain and controls PP1 activity and F-actin remodelling. Genome-wide association studies (GWASs) implicate the Phactr-1 locus (6p24) as a risk factor for five vascular diseases, including...
ORGANISM(S): Homo sapiens 
2022-08-16 | GSE186761 | GEO
GenomicsTranscriptomic profiling of Phactr1 overexpression in human endothelial cells
Transcriptomic profiling of Phactr1 overexpression in human endothelial cells
PRJNA775982 | ENA
GenomicsRNA-seq of PHACTR1 knockdown and overexpression in HT1080 stable cell lines
RNA-seq of PHACTR1 knockdown and overexpression in HT1080 stable cell lines
PRJEB97469 | ENA
UnknownMulti-omic analysis of human PHACTR1 signaling networks.
Not available
S-EPMC12913993 | biostudies-literature
UnknownPHACTR1 splicing isoforms and eQTLs in atherosclerosis-relevant human cells.
Not available
S-EPMC5994109 | biostudies-literature
UnknownPHACTR1, a coronary artery disease risk gene, mediates endothelial dysfunction.
Not available
S-EPMC9457086 | biostudies-literature
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