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TranscriptomicsSelective inhibition of Homo sapiens M1 macrophages where SP140 mRNA is inhibited using siRNA
As part of our study in understanding the role of SP140 in inflammatory pathways in macrophages, we inhibited SP140 mRNA using siRNA. Peripheral blood mononuclear cells (PBMCs) were obtained from whole blood of healthy donors (from Sanquin Institute Amsterdam or from GSK Stevenage Blood Donation U...
ORGANISM(S): Homo sapiens 
2022-07-22 | E-MTAB-12011 | biostudies-arrayexpress
GenomicsRemodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers, thereby enabling signal-dependent transcription factors to bind and function in a cell type-specific manner. Consistent with this model, TLR4 si...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-48759 | biostudies-arrayexpress
GenomicsA Case-Controlled Study for Genotype-Phenotype Associations in Multiple Sclerosis (MS)

This is a multi-centre, case-controlled study to develop a dataset containing 1000 MS cases and 1000 matched controls and to associate DNA sequence (allelic) variations with MS phenotypes.

Study subjects were enrolled through a prospective effort initiated in 2003. Three MS clinical ce...

phs000171.v1.p1 | EGA
TranscriptomicsRNA-seq of synovial biopsies from rheumatoid arthritis patients
Synovial biopsies from rheumatoid arthritis patients were obtained and profiled using RNA-seq. Patients were stratified according to the number of swollen joints they had (SJC, swollen joint count) and divided in three groups for the differential expression analysis: None (SJC = 0), Low (1<= SJC <= ...
ORGANISM(S): Homo sapiens 
2021-04-26 | E-MTAB-6684 | biostudies-arrayexpress
TranscriptomicsTreatment of myeloma cell lines with the bromodomain inhibitor I-BET151
KMS12BM and H929 myeloma cells were treated in vitro with either I-BET151 1uM or vehicle (DMSO) for 6 hours (n=3 independent experiments for each cell line). Total RNA was extracted from H929 and KMS12BM cells using the RNeasy Mini kit (Qiagen). Genomic DNA contamination was eliminated using colum...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-MTAB-2122 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of hPAF1 deficiency on unstimulated A549 cells
Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 targets t...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35265 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of hPAF1 deficient A549 cells during infection with H1N1 influenza A virus or vesicular stomatitis virus (VSV)
Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 targets t...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35266 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of hPAF1 deficient A549 cells during stimulation with PR8/∆NS1 influenza virus, IFNβ1 or Poly(I:C)
Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 targets t...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35267 | biostudies-arrayexpress
TranscriptomicsGSK8814: a chemical probe fort he ATAD2 bromodomain
Differential gene expression analysis of LNCaP cells treated with GSK8814 and GSK8815 Total RNA obtained from cells treated with GSK8814 and GSK8815 for 24 hours
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-78868 | biostudies-arrayexpress
TranscriptomicsAutism-like syndrome is induced in mice by pharmacological suppression of BET proteins
Studies investigating the causes of autism spectrum disorder (ASD) point to genetic as well as epigenetic mechanisms of the disease. Identification of epigenetic processes that contribute to ASD development and progression is of major importance and may lead to the development of novel therapeutic s...
ORGANISM(S): Mus musculus 
2015-09-09 | E-GEOD-72149 | biostudies-arrayexpress
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