H1299 cells expressing tetracycline regulated (“tet-off”) delta30 p53 (delta364-393) were previously described (Chen et al., 1996; McKinney et al., 2004).
p53 is a frequent target for mutation in human tumors and previous studies have revealed that these missense mutant proteins can actively contribute to tumorigenesis. To elucidate how mutant p53 might contribute to mammary carcinogenesis we employed a three-dimensional (3D) culture model. In 3D cul...
