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MetabolomicsLKB1 inactivation elicits a NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer
The protein arginine methyl transferase 5 (PRMT5) emerges as a therapeutic target in S-methyl-5'-thioadenosine phosphorylase (MTAP)-deleted cancers, where MTA accumulation partially inhibits its activity. However, It remains unclear whether other genetic alterations can dictate PRMT5 activity in can...
2026-04-30 | MTBLS14411 | MetaboLights
GenomicsPRMT5 genomic deregulation supports growth and stress tolerance in chronic lymphocytic leukemia
Patients suffering from chronic lymphocytic leukemia (CLL) display highly diverse clinical courses ranging from indolent cases to aggressive disease with genetic and epigenetic features resembling this diversity. Here, we developed a comprehensive approach combining a variety of molecular and clinic...
ORGANISM(S): Homo sapiens 
2020-08-19 | E-MTAB-8203 | biostudies-arrayexpress
ProteomicsPCK2-mediated PQBP1 lactylation promotes asthmatic inflammation through PRMT5 inhibition
Background: Asthma involves chronic inflammation linked to metabolic reprogramming, but how metabolites reshape epigenetics through post-translational modifications remains unclear. Methods: We used HDM-induced asthmatic mice with multi-omics analyses (metabolomics, PTM-proteomics, ChIP-seq) and val...
ORGANISM(S): Homo Sapiens 
2025-11-12 | PXD070618 |
GenomicsPRMT5 inhibition in MCL
PRMT5 inhibition in MCL
PRJNA912113 | ENA
ProteomicsDisruption of splicing, proliferation and stemness via PRMT5 inhibition as a therapeutic strategy for GBM
Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor growth and contribute to therapeutic resistance. Protein Arginine Methyltransferase 5 (PRMT5) has recently emerged as a promising target in GBM. Using two orthogonal-acting inhibitors of PRMT5 (GSK591 or LLY-283), ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-03 | PXD021635 | Pride
Cancer Proteomics Glioblastoma Prmt5 inhibition 
GenomicsAntitumor effects of PRMT5 inhibition in sarcomas
Antitumor effects of PRMT5 inhibition in sarcomas
PRJNA1019762 | ENA
ProteomicsGlutathionylation decreases methyltransferase activity of PRMT5 and inhibits cell proliferation
Glutathionylation is an important posttranslational modification that protects proteins from further oxidative damage as well as influencing protein structure and activity. In the present study, we demonstrate that the cysteine-42 residue in protein arginine N-methyltransferase 5 (PRMT5) is glutathi...
ORGANISM(S): Homo sapiens (Human) 
2020-09-02 | PXD020428 | Pride
Glutathionylation Methyltransferase activity Protein arginine n-methyltransferase 5 (prmt5) Reactive oxygen species (ros) Binding affinity 
GenomicsTranscriptional modulation by PRMT5 inhibition with EPZ015666 (GSK3235025)
Transcriptional modulation by PRMT5 inhibition with EPZ015666 (GSK3235025)
PRJNA1032548 | ENA
GenomicsPRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide
PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide
PRJNA1209912 | ENA
TranscriptomicsPRMT5 genomic deregulation supports growth and stress tolerance in chronic lymphocytic leukemia
Patients suffering from chronic lymphocytic leukemia (CLL) display highly diverse clinical courses ranging from indolent cases to aggressive disease with genetic and epigenetic features resembling this diversity. Here, we developed a comprehensive approach combining a variety of molecular and clinic...
ORGANISM(S): Homo sapiens 
2020-08-19 | E-MTAB-8219 | biostudies-arrayexpress
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