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TranscriptomicsTranscription profiling of human cell lines under bioreductive prodrug PR-104A
A variety of human cell lines, were grown, RNA was extracted, and gene expression quantified using Affymetrix hgu133plus2 arrays. Expression of genes was compared to the rate of metabolism of the bioreductive prodrug PR-104A, and genes with expression shown to be statistically significantly correla...
ORGANISM(S): Homo sapiens 
2009-08-25 | E-TABM-767 | biostudies-arrayexpress
MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. congolense assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-10-22 | MTBLS1309 | MetaboLights
GenomicsGliocidin is a nicotinamide mimetic prodrug that targets glioblastoma
Gliocidin is a nicotinamide mimetic prodrug that targets glioblastoma
PRJNA1161693 | ENA
GenomicsExpression data from THP1-wt and THP1-NTR+ cells with LSD1 inhibitor (OG86), Nitroreductase NfsB (NTR) prodrug and negative control
Expression data from THP1-wt and THP1-NTR+ cells with LSD1 inhibitor (OG86), Nitroreductase NfsB (NTR) prodrug and negative control
PRJNA650534 | ENA
TranscriptomicsExpression data from THP1-wt and THP1-NTR+ cells with LSD1 inhibitor (OG86), Nitroreductase NfsB (NTR) prodrug and negative control
The Nitroreductase NfsB (NTR) prodrug of an LSD1 inhibitor is inactive in wild-type THP1 cells, but the prodrug gets activated in the LSD1 inhibitor by the NTR in NTR-expressing THP1 cells (THP1-NTR+). Cell-type specific inhibition of LSD1 in THP1-NTR+ cells with a NTR prodrug is shown with the expr...
ORGANISM(S): Homo sapiens 
2020-08-04 | GSE155640 | GEO
TranscriptomicsAnalyses of mIRNA transcript level following exposure to triptolide
Analyses of mirna transcript levels following exposure to the drug triptolide in vitro and prodrug minnelide in xenograft pancreatic tumor mouse models. Response of pancreatic adenocarcinoma cell lines to minelide in vitro and exposure to its prodrug triptolide in SCID mouse tumors derived from the ...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-46188 | biostudies-arrayexpress
TranscriptomicsGliocidin is a nicotinamide mimetic prodrug that targets glioblastoma
Glioblastoma is incurable and in urgent need of improved therapeutics. We identify a small compound, Gliocidin, that kills glioblastoma cells while sparing nontumor replicative cells. Gliocidin activity targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of i...
ORGANISM(S): Homo sapiens Mus musculus 
2024-10-30 | GSE277301 | GEO
UnknownTetrazine-mediated bioorthogonal prodrug-prodrug activation.
Not available
S-EPMC6148199 | biostudies-literature
ProteomicsProteomics-Based Retinal Target Engagement Analysis and Retina-Targeted Delivery of 17β-Estradiol by the DHED Prodrug in Males. Katalin Prokai-Tatrai,* Khadiza Zaman, Vien Nguyen, Daniel L. De La Cruz and Laszlo Prokai
We examined the impact of 17β-estradiol (E2) eye drops on the modulation of the proteome pro-file in the male rat retina. With discovery-driven proteomics, we have identified proteins that were regulated by the treatment. These proteins were assembled to several bioinformatics-based networks implica...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-11-04 | PXD027902 | Pride
Prote-omics Isotope-dilution Targeted proteomics Dhed prodrug Neuroprotection  lc-ms/ms 17β-estradiol  e2  eye drops  male retina  parallel-reaction monitoring 
GenomicsA Glutamine Antagonist Prodrug Reprograms Dendritic Cells to Enhance Colorectal Cancer Immunotherapy
A Glutamine Antagonist Prodrug Reprograms Dendritic Cells to Enhance Colorectal Cancer Immunotherapy
PRJNA1260465 | ENA
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