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ProteomicsA proteomics study identifying interactors of the FSHD2 gene product SMCHD1 reveals RUVBL1-dependent DUX4 repression.
Structural Maintenance of Chromosomes Hinge Domain Containing 1 (SMCHD1) is a chromatin repressor, which is mutated in >95% of Facioscapulohumeral dystrophy (FSHD) type 2 cases. In FSHD2, SMCHD1 mutations ultimately result in the presence of the cleavage stage transcription factor DUX4 in muscle cel...
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD023993 | Pride
Smchd1  fshd  ruvbl1  silac  ezhip 
UnknownA Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb's Release from 7SK snRNP.
Not available
S-EPMC4646521 | biostudies-literature
ProteomicsQuantitative proteomics reveals the dynamic proteome landscape of zebrafish embryos during maternal-to-zygotic transition and its relationship to zygotic genome activation
Upon fertilization, the embryonic genome remains transcriptionally inactive until the mid-blastula transition. Zygotic genome activation (ZGA) of vertebrate embryos has been extensively studied using nucleic acid-based strategies, but proteomics data are still scarce, impeding the full mechanistic u...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Xenopus laevis (African clawed frog) 
2024-05-01 | PXD036678 | Pride
Zygotic genome activation Zebrafish embryo Maternal-to-zygotic transition Quantitative proteomics 
TranscriptomicsMitohormesis reprograms macrophage metabolism to enforce tolerance [BMDM_OHestrogen_RNAseq]
Macrophages generate mitochondrial reactive oxygen and electrophilic species (mtROS, mtRES) as antimicrobials during Toll-like receptor (TLR)-dependent inflammatory responses. Whether mitochondrial stress caused by these molecules impacts macrophage function is unknown. Here, we demonstrate that bot...
ORGANISM(S): Mus musculus 
2021-04-04 | GSE169727 | GEO
TranscriptomicsMitohormesis reprograms macrophage metabolism to enforce tolerance [vWAT_mac_RNAseq]
Macrophages generate mitochondrial reactive oxygen and electrophilic species (mtROS, mtRES) as antimicrobials during Toll-like receptor (TLR)-dependent inflammatory responses. Whether mitochondrial stress caused by these molecules impacts macrophage function is unknown. Here, we demonstrate that bot...
ORGANISM(S): Mus musculus 
2021-04-04 | GSE169728 | GEO
TranscriptomicsMitohormesis reprograms macrophage metabolism to enforce tolerance [BMDM_tolerance_RNAseq]
Macrophages generate mitochondrial reactive oxygen and electrophilic species (mtROS, mtRES) as antimicrobials during Toll-like receptor (TLR)-dependent inflammatory responses. Whether mitochondrial stress caused by these molecules impacts macrophage function is unknown. Here, we demonstrate that bot...
ORGANISM(S): Mus musculus 
2021-04-04 | GSE169730 | GEO
GenomicsMitohormesis reprograms macrophage metabolism to enforce tolerance [BMDM_ChIPseq]
Macrophages generate mitochondrial reactive oxygen and electrophilic species (mtROS, mtRES) as antimicrobials during Toll-like receptor (TLR)-dependent inflammatory responses. Whether mitochondrial stress caused by these molecules impacts macrophage function is unknown. Here, we demonstrate that bot...
ORGANISM(S): Mus musculus 
2021-04-04 | GSE169729 | GEO
UnknownSynthetic (+)-antroquinonol exhibits dual actions against insulin resistance by triggering AMP kinase and inhibiting dipeptidyl peptidase IV activities.
Not available
S-EPMC4280966 | biostudies-literature
GenomicsGenome-wide distribution of AdpA, a global regulator for secondary metabolism and morphological differentiation in Streptomyces [liquid]
AdpA is a global transcriptional activator triggering morphological differentiation and secondary metabolism in Streptomyces griseus. AdpA influences expression of >1,000 genes, but the overall picture of AdpA regulon has been obscure. Here, we took snapshots of distribution of AdpA across the chrom...
ORGANISM(S): Streptomyces griseus 
2012-04-03 | E-GEOD-34036 | biostudies-arrayexpress
UnknownTriggering a switch from basal- to luminal-like breast cancer subtype by the small-molecule diptoindonesin G via induction of GABARAPL1.
Not available
S-EPMC7429843 | biostudies-literature
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