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TranscriptomicsTranscription profiling of mouse E10.5 female embryos wild-type and mutant for Smchd1
To investigate the role of the Smchd1 protein in epigenetic silencing of autosomal loci, we carried out a comparative microarray gene expression analysis of wild-type and Smchd1-/- female embryos at E10.5. Embryos were collected at E10.5 after natural mating, sexed and genotyped. Total RNAs were ext...
ORGANISM(S): Mus musculus 
2012-04-01 | E-MTAB-921 | biostudies-arrayexpress
ProteomicsA proteomics study identifying interactors of the FSHD2 gene product SMCHD1 reveals RUVBL1-dependent DUX4 repression.
Structural Maintenance of Chromosomes Hinge Domain Containing 1 (SMCHD1) is a chromatin repressor, which is mutated in >95% of Facioscapulohumeral dystrophy (FSHD) type 2 cases. In FSHD2, SMCHD1 mutations ultimately result in the presence of the cleavage stage transcription factor DUX4 in muscle cel...
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD023993 | Pride
Smchd1  fshd  ruvbl1  silac  ezhip 
GenomicsGenome-wide binding and mechanistic analyses of Smchd1 mediated epigenetic regulation [ChIP-Seq, MBD-Seq]
Purpose: The aim of this study is (1) to identify the chromatin occupancy of the epigenetic regulator Smchd1 in neural stem cells (NSCs) derived from E14.5 mouse brain; (2) to profile key epigenetic marks H3K4me3, H3K27me3 and DNA methylation in wild type and Smchd1 null NSCs; (3) to identify the ch...
ORGANISM(S): Mus musculus 
2015-06-11 | E-GEOD-65748 | biostudies-arrayexpress
GenomicsSmchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.
X chromosome inactivation involves multiple levels of chromatin modification, established progressively and in a stepwise manner during early development. The chromosomal protein Smchd1 has recently been shown to play an important role in DNA methylation of CpG islands (CGIs), a late step in the X i...
ORGANISM(S): Mus musculus 
2012-10-15 | E-GEOD-37333 | biostudies-arrayexpress
GenomicsThe role of SMCHD1 in the formation of constitutive heterochromatin
A large portion of the mammalian genome is assembled into constitutive heterochromatin which is highly compact and transcriptionally silent throughout the cell cycle. On the molecular level it is characterized by DNA methylation, “repressive” histone marks (hypoacethylation, H3K9 trimethylation, H4K...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-46462 | biostudies-arrayexpress
GenomicsATAC-seq in Smchd1 wild-type and Smchd1 deleted neural stem cells.
ATAC-seq in Smchd1 wild-type and Smchd1 deleted neural stem cells.
PRJNA437971 | ENA
GenomicsRNA-seq in Smchd1 wild-type and Smchd1 deleted differentiating male ES cells.
RNA-seq in Smchd1 wild-type and Smchd1 deleted differentiating male ES cells.
PRJNA437972 | ENA
GenomicsRNA-seq in Smchd1 wild-type and Smchd1 null presomitic mesoderm from E9.5 embryos
RNA-seq in Smchd1 wild-type and Smchd1 null presomitic mesoderm from E9.5 embryos
PRJNA439000 | ENA
GenomicsRRBS in Smchd1 control and Smchd1 deleted male and female neural stem cells.
RRBS in Smchd1 control and Smchd1 deleted male and female neural stem cells.
PRJNA476548 | ENA
GenomicsIn situ Hi-C in Smchd1 wild-type and Smchd1 deleted neural stem cells.
In situ Hi-C in Smchd1 wild-type and Smchd1 deleted neural stem cells.
PRJNA437969 | ENA
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