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TranscriptomicsTranscription profiling of brain and spleen from rhesus macaque to validate two oligonucleotide array
We constructed a database containing 248,000 exon sequences from 23,000 human RefSeq genes and compared each human exon with its best matching sequence in the January 2005 version of the rhesus genome project list of 486,000 DNA contigs. Best matching rhesus exon sequences for each of the 23,000 hum...
ORGANISM(S): Macaca mulatta 
2007-01-10 | E-TABM-189 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression in human hepatitis c virus (HCV) liver biopsy samples
In order to infer the inverse expression relationships between microRNAs and mRNAs during HCV infection, we profiled both microRNA and mRNA expressions in HCV positive (HCV+) and HCV negative (HCV-) human liver biopsy tissue samples. This series includes all microRNA profiles. This series includes m...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-15288 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bronchus from macaques infected with either the 1918 influenza virus or a humanized contemporary H1N1 influenza virus
The 1918 influenza pandemic was unusually severe, resulting in about 50 million deaths worldwide. A reconstructed version of the 1918 (H1N1) virus has been shown to also highly pathogenic in mice; however, the potential virulence and pathogenicity of the 1918 virus in nonhuman primates in unknown. ...
ORGANISM(S): Macaca fascicularis 
2007-01-18 | E-TABM-181 | biostudies-arrayexpress
TranscriptomicsEffect of isoflavone agonists of IRF-3 on response to RNA viruses
There is a growing need for novel antiviral therapies that are broad-spectrum, effective, and not subject to resistance due to viral mutations. Using high-throughput screening methods, including computational docking studies and an ISG54-luciferase reporter assay, we identified a class of isoflavone...
ORGANISM(S): Homo sapiens 
2012-05-17 | E-GEOD-38016 | biostudies-arrayexpress
TranscriptomicsAcute host transcriptonal response to r1918 influenza and r1918 influenza containing the NS1 gene from A/Texas/36/91 in A549 cells
The “Spanish influenza” of 1918 claimed an unprecedented number of lives, yet the determinants of virulence for this virus are still not fully understood. Here, we used functional genomics and an in vitro human lung epithelial cell infection model to define the global host transcriptional response t...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-37951 | biostudies-arrayexpress
TranscriptomicsIntegrative deep sequencing of the mouse lung transcriptome reveals differential expression of diverse classes of small RNAs in response to respiratory virus infection.
We previously reported widespread differential expression of long non-protein-coding RNAs (ncRNAs) in response to virus infection. Here, we expanded the study through small RNA transcriptome sequencing analysis of the host response to both severe acute respiratory syndrome coronavirus (SARS-CoV) and...
ORGANISM(S): Mus musculus 
2012-03-31 | E-GEOD-36971 | biostudies-arrayexpress
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