Sort   by:  
 Page size 
TranscriptomicsChromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.
A global view of PML-RAR? transcriptional functions was obtained by genome-wide binding and chromatin modification analyses, combined with genome wide expression data. Complete Abstract: The translocation t(15;17) generates the chimeric PML-RAR? transcription factor that is the initiating event of ...
ORGANISM(S): Homo sapiens 
2008-09-06 | E-GEOD-12641 | biostudies-arrayexpress
GenomicsPML-RARa/RXR alters the epigenetic landscape in Acute Promyelocytic Leukemia
Many different molecular mechanisms have been suggested to be associated with PML-RAR dependent transformation of haematopoietic progenitors. Here, we investigated the role of PML-RAR and RXR in the organization of epigenetic structures at a genome-wide level. We identified 2722 high confidence PML-...
ORGANISM(S): Homo sapiens 
2009-12-17 | E-GEOD-18886 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of pediatric acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is categorized as the M3 subtype in the French-American-British classification system. It represents a unique subtype of acute myeloid leukemia (AML) characterized by the t(15;17)/PML::RARA fusion, with leukemic cells arrested at the promyelocytic stage of myelopoi...
ORGANISM(S): Homo sapiens 
2026-08-01 | E-MTAB-15728 | biostudies-arrayexpress
GenomicsDNA methylation changes are a late event in Acute Promyelocytic Leukemia and coincide with loss of transcription factor binding (sequencing)
The origin of aberrant DNA methylation in cancer remains largely unknown. In this study, we elucidated the DNA methylome in primary Acute Promyelocytic Leukemia (APL) and the role of PML-RARa in establishing these patterns. APL patients showed increased genome-wide DNA methylation with higher variab...
ORGANISM(S): Homo sapiens 
2012-11-08 | E-GEOD-42044 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of pediatric acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is categorized as the M3 subtype in the French-American-British classification system. It represents a unique subtype of acute myeloid leukemia (AML) characterized by the t(15;17)/PML::RARA fusion, with leukemic cells arrested at the promyelocytic stage of myelopoi...
ORGANISM(S): Homo sapiens 
2026-08-01 | E-MTAB-15773 | biostudies-arrayexpress
GenomicsThe ability of PML/RARα to initiate leukemia is associated with markedly increased proliferation of promyelocytes despite minor changes in the transcriptome and epigenome.
Acute Promyelocytic Leukemia is characterized by the accumulation in the blood and bone marrow of promyelocytes. The PML/RARα fusion protein is identified as the primary abnormality implicated in the pathology, and is believed to prevent transcription of genes necessary for normal myeloid developmen...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-54038 | biostudies-arrayexpress
TranscriptomicsSNP data of acute promyelocytic leukemia samples
Acute promyelocytic leukemia (APL) is a hematopoietic malignant disease characterized by the chromosomal translocation t(15;17), resulting in the formation of the PML-RARA gene. Here, 47 t(15;17) APL samples were analyzed with high-density single-nucleotide polymorphism microarray (50K and 250K SNP...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-14016 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of blasts from three APL patients expressing PML/RAR before and after treatment with 1 uM retinoic acid (RA) in vitro for four hours
Gene expression profiles in blasts from three APL patients expressing PML/RAR were assessed before and after treatment with 1 uM retinoic acid (RA) in vitro for four hours. We then studied a U937 clone conditionally expressing PML/RAR (U937-PR), (Grignani et al. 1993) (Alcalay et al. 2003), and comp...
ORGANISM(S): Homo sapiens 
2004-12-31 | E-MEXP-149 | biostudies-arrayexpress
TranscriptomicsDifferential IFNa-stimulated gene expression profiles in PLZF-inducible U937T monocyte cells
Sensitivity to Interferon (IFN) is determined by a complex coordination of genetic and environmental factors. A previous experiment using two renal cancer cell lines differing markedly in their response to IFN were analyzed for their ISG profiles in order to determine gene expression changes associa...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-16196 | biostudies-arrayexpress
TranscriptomicsEffect of PML/RARA on the transcriptome of preleukemic early promyelocytes vs PML/RARA-Flt3ITD leukemic promyelocytes
Transcriptional profiling of murine cells expressing PML/RARA at the early promyelocyte stage (4 weeks old, preleukemic) and in full blown PML/RARA leukemia generated by transducing PML/RARA bone marrow with a Flt3-ITD retroviral vector Two-conditions experiment: preleukemic early promyelocytes vs l...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-59431 | biostudies-arrayexpress
Sort   by:  
 Page size