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MetabolomicsGut Microbiota-Derived Indole-3-Propionic Acid Ameliorates Diabetic Cardiomyopathy by Regulating Mitochondrial Dynamics via the AhR/Nrf2 Pathway
This study investigated serum metabolic alterations in a mouse model of diabetic cardiomyopathy and evaluated the protective role of the gut microbiota-derived metabolite indole-3-propionic acid. Serum samples from mice were analyzed using untargeted LC-MS metabolomics. The study focused on the rela...
2026-07-26 | MTBLS14953 | MetaboLights
MetabolomicsMicrobiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice
Anti-programmed death 1 (αPD1) immune checkpoint blockade is used in combination for cancer treatment but associated with cardiovascular toxicity. Finding drugs that suppress cardiovascular toxicity but not compromise the efficacy of αPD1-mediated immunotherapy is of great importance. Leflunomide (L...
2025-03-12 | MTBLS12066 | MetaboLights
MetabolomicsComparative metabolomics analysis of the key metabolic nodes in propionic acid synthesis in Propionibacterium acidipropionici
Not available
ORGANISM(S): Acidipropionibacterium acidipropionici 
ST000116 | MetabolomicsWorkbench
ProteomicsPropionic acid promotes neurite recovery in damaged multiple sclerosis neurons
Neurodegeneration in the autoimmune disease multiple sclerosis (MS) still poses a major therapeutic challenge. Effective drugs that target the inflammation can only partially reduce accumulation of neurological deficits and conversion to progressive disease forms. Diet and the associated gut microbi...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD040184 | Pride
Propionic acid Neurons Microbiome Ipscs Multiple sclerosis Damage Neurodegeneration 
TranscriptomicsEffect of topical application of propionic acid on gene expression in the skin lesions of AD mice
Secondary metabolites such as short chain fatty acids (SCFAs) are primarily responsible for skin microbiota to modulate skin homeostasis. We here report propionic acid can relieve AD in mice. To further explore the mechanism underlying the modulation of skin microbiota-derived propionic acid on AD, ...
ORGANISM(S): Mus musculus 
2026-06-30 | GSE270153 | GEO
GenomicsEffect of topical application of propionic acid on gene expression in the skin lesions of AD mice
Effect of topical application of propionic acid on gene expression in the skin lesions of AD mice
PRJNA1125347 | ENA
MetabolomicsEvidence of a DHA signature in the lipidome and metabolome of human hepatocytes
Cell supplementation with bioactive molecules often causes a perturbation in the whole intracellular environment. Omics techniques can be applied for the assessment of this perturbation. In this study, the overall effect of docosahexaenoic acid (DHA) supplementation on cultured human hepatocyte lipi...
2017-03-02 | MTBLS419 | MetaboLights
Genomics
propionic acid inhibition
PRJNA1212302 | ENA
MetabolomicsSkeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves
The effects of different amino acid (AA) supplementations of milk protein-based milk replacers in pre-ruminant calves from 3 days to 7 weeks of age were studied. Animals were divided into 4 groups: Ctrl) Control group fed with milk protein-based milk replacer without supplementation; GP) supplementa...
2018-10-08 | MTBLS720 | MetaboLights
UnknownHigh prevalence of self-reported autism spectrum disorder in the Propionic Acidemia Registry.
Not available
S-EPMC7012741 | biostudies-literature
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