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MetabolomicsRabbit plasma metabolomic analysis of Nitroproston: a multi target natural prostaglandin based-drug (Untargeted study)
INTRODUCTION: Nitroproston® is a novel multi-target drug bearing natural prostaglandin E2 (PGE2) and nitric oxide (NO)-donating fragments for treatment of inflammatory and obstructive diseases (i.e. asthma and obstructive bronchitis). OBJECTIVES: To investigate the effects of Nitroproston® adm...
2019-08-27 | MTBLS727 | MetaboLights
TranscriptomicsProstaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4
Recognition of foreign antigens by B cell receptor (BCR) on mature B cells leads to their clonal expansion, which is critically important for the effective host defence of the organism. However, excessive antigenic responses or reaction of B cells against body’s own components frequently lead to d...
ORGANISM(S): Mus musculus 
2008-12-14 | E-GEOD-9847 | biostudies-arrayexpress
TranscriptomicsProstaglandin dose response on hematopoietic stem cells (4 deg C)
Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count, which is associated with de...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-46634 | biostudies-arrayexpress
TranscriptomicsProstaglandin duration required to elicit maximum response on hematopoietic stem cells
Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count, which is associated with de...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-46714 | biostudies-arrayexpress
TranscriptomicsProstaglandin dose response on hematopoietic stem cells (25 & 37 deg C)
Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count, which is associated with del...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-48541 | biostudies-arrayexpress
TranscriptomicsProstaglandin-modulated umbilical cord blood hematopoietic stem cells
Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count, which is associated with de...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-46569 | biostudies-arrayexpress
TranscriptomicsComparative genomic analysis of human and non-human primate CD34+ MPBSCs exposed to PGE2
Abstract: Hematopoietic stem cells (HSCs) are used in transplantation therapy to reconstitute the hematopoietic system. Human cord blood (hCB) transplantation has emerged as an attractive alternative treatment option when traditional HSC sources are unavailable, however, the absolute number of hCB H...
ORGANISM(S): Macaca mulatta 
2012-06-24 | E-GEOD-27126 | biostudies-arrayexpress
TranscriptomicsMicroglial response to A? and prostaglandin-E2 EP4 receptor activation
A persistent and non-resolving inflammatory response to accumulating A? peptide species is a cardinal feature in the development of Alzheimer's disease (AD). In response to accumulating A? peptide species, microglia, the innate immune cells of the brain, generate a toxic inflammatory response that a...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-55627 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse gastric tumor models
Transgenic mice with prostaglandin E2 pathway in stomach develops gastric tumors. Simultaneous activation of both Wnt pathway and prostaglandin E2 pathway causes gastric adenocarcinoma. Combination of prostaglandin E2 pathway activation and suppression of BMP pathway leads to the development of gast...
ORGANISM(S): Mus musculus 
2009-07-02 | E-GEOD-16902 | biostudies-arrayexpress
TranscriptomicsPGE2 promotes recovery from established Nephrotoxic Serum Nephritis in mice.
We induced acute nephritis by single injection of sheep nephrotoxic serum in mice and then treated the mice with prostaglandin E2. We used microarrays to examine the global gene expressions during recovery from nephrotoxic nephritis by prostaglandin E2. Acute nephristis was induced in female mice b...
ORGANISM(S): Mus musculus 
2012-04-22 | E-GEOD-37402 | biostudies-arrayexpress
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