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MetabolomicsMuscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males

Reduced estrogen action is associated with obesity and insulin resistance. However, the cell and tissue-specific actions of estradiol in maintaining metabolic health remain inadequately understood, especially in men. We observed that skeletal muscle ESR1/Esr1 (encodes estrogen receptor α) is posi...

2025-04-09 | MTBLS914 | MetaboLights
MetabolomicsThe putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast (Lipidome assay)
Cellular nutrient states control whether cells proliferate, or whether they enter or exit quiescence. Here, we report characterizations of fission yeast temperature-sensitive (ts) mutants of the evolutionarily conserved transmembrane protein, Cwh43, and explore its relevance to utilization of glucos...
2018-08-21 | MTBLS578 | MetaboLights
MetabolomicsThe putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast (Metabolome assay)
Cellular nutrient states control whether cells proliferate, or whether they enter or exit quiescence. Here, we report characterizations of fission yeast temperature-sensitive (ts) mutants of the evolutionarily conserved transmembrane protein, Cwh43, and explore its relevance to utilization of glucos...
2018-08-17 | MTBLS577 | MetaboLights
GenomicsThe genetic architecture of protein stability
The genetic architecture of protein stability
PRJNA1032554 | ENA
GenomicsIn vivo probing of the DNA-binding Architecture by bacterial arginine repressor
Although DNA motifs recognized by the transcription factors (TFs) have been determined, challenges remain in probing in vivo architecture of TF-DNA complexes on a genome-wide scale. Here, we show in vivo architecture of Escherichia coli arginine repressor (ArgR)-DNA complexes using chromatin immunop...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2015-04-01 | E-GEOD-60546 | biostudies-arrayexpress
GenomicsArchitectural protein subclasses shape 3-D organization of genomes during lineage commitment
Understanding the topological configurations of chromatin can reveal valuable insights into how the genome and epigenome act in concert to control cell fate during development. Here we generate high-resolution architecture maps across seven genomic loci in embryonic stem cells and neural progenitor...
ORGANISM(S): Mus musculus 
2013-05-24 | E-GEOD-36203 | biostudies-arrayexpress
MetabolomicsGNPS - Metabolite-protein covariation architecture identified a cysteine shunt regulating liver cholesterol
Metabolomics raw data for manuscript Xiao, H. et al. "Metabolite-protein covariation architecture identified a cysteine shunt regulating liver cholesterol".
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2025-06-24 | MSV000098306 | GNPS
GenomicsThe genetic architecture of protein interaction affinity and specificity
The genetic architecture of protein interaction affinity and specificity
PRJNA1027833 | ENA
GenomicsHiChIP: Efficient and sensitive analysis of protein-directed genome architecture
HiChIP: Efficient and sensitive analysis of protein-directed genome architecture
PRJNA320090 | ENA
GenomicsThe effect of bound RSC/nucleosome complex on chromatin architecture and gene expression at the GAL genes of yeast
How is chromatin architecture established and what role does it play in activation of transcription? We show that a regulatory locus in yeast (the UASg) bears, in addition to binding sites for the activator Gal4, sites bound by the protein RSC. RSC tightly positions a nucleosome, evidently partial...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-01 | E-GEOD-20078 | biostudies-arrayexpress
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