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TranscriptomicsCharacterization of Gene Expression in ASS1-Deficient Breast Cancer Cells
Analysis of mechanism underlying the metabolic effects of ADI-PEG20 at gene expression level. The hypothesis tested in the present study was that ASS1-deficient breast cancer cells would be arginine-auxotrophs and would therefore be sensitive to arginine starvation. Results provide important informa...
ORGANISM(S): Homo sapiens 
2014-05-20 | E-GEOD-53838 | biostudies-arrayexpress
ProteomicsSystems level profiling of arginine starvation in ASS1 negative sarcomas reveals ERK and MYC adaptive metabolic reprogramming of TCA anaplerosis and lipid metabolism
submission for the paper "Systems level profiling of arginine starvation in ASS1 negative sarcomas reveals ERK and MYC adaptive metabolic reprogramming of TCA anaplerosis and lipid metabolism"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-09 | MSV000084785 | MassIVE
TranscriptomicsCitrullination of Histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma
Multiple myeloma (MM), an incurable plasma cell malignancy, requires localisation within the bone marrow in order to survive and proliferate. Interactions between the malignant plasma cell and bone marrow mesenchymal stem cell (BMMSC) are thought to be a critical determinant of this requirement, and...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-80608 | biostudies-arrayexpress
UnknownProtein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation.
Not available
S-EPMC7319962 | biostudies-literature
UnknownPegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism.
Not available
S-EPMC8784773 | biostudies-literature
UnknownAn improved synthesis of haloaceteamidine-based inactivators of protein arginine deiminase 4 (PAD4).
Not available
S-EPMC2597826 | biostudies-literature
ProteomicsProteomics of THP-1 macrophages polarization to M1 and M2 phenotype and treated with BB-Cl-amidine
Macrophages are effector cells of the innate immune system and undergo phenotypical changes in response to organ injury and repair. They are most often classified as proinflammatory M1 and anti-inflammatory M2 macrophages. Protein arginine deiminase (PAD) enzymes, that catalyze the conversion of pr...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD034591 | Pride
Swath Protein arginine deiminase Citrullination Macrophages polarization 
UnknownAntibody discovery identifies regulatory mechanisms of protein arginine deiminase 4.
Not available
S-EPMC11142921 | biostudies-literature
UnknownProtein arginine deiminase 4: evidence for a reverse protonation mechanism.
Not available
S-EPMC2212595 | biostudies-literature
UnknownInhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.
Not available
S-EPMC1808342 | biostudies-literature
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