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TranscriptomicsDatabase for mRNA Half-Life of 19,977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse
Degradation of mRNA is one of the key processes that control the steady-state level of gene expression. However, the rate of mRNA decay for the majority of genes is not known. We successfully obtained the rate of mRNA decay for 19 977 non-redundant genes by microarray analysis of RNA samples obtaine...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-13609 | biostudies-arrayexpress
Proteomics,MultiomicsDynamic profiling of the protein life cycle in response to pathogens
Jovanovic M,Rooney M, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach M, Eisenhaure T, Rabani M, Gennert D, Lu D, Delorey T, Weissman JS, Carr SA, Hacohen N, Regev A, submitted 2015. Protein expression is regulated by production and degrada...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-01-15 | MSV000078994 | MassIVE
TranscriptomicsTranscription profiling of human B-cells and mouse NIH-3T3 cells for analysis of RNA synthesis, abundance and decay
This SuperSeries is composed of the following subset Series:; GSE9973: Half-life determination for human B-cells (BL41); GSE9975: newly transcribed RNA (nt-RNA) for IFN alpha and gamma time course; GSE9977: Expression data from NIH-3T3 cells treated with mock, 100 U/ml IFN alpha or 100 U/ml gamma fo...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-10026 | biostudies-arrayexpress
ProteomicsDynamic profiling of the protein life cycle in response to pathogens (protein)
Protein expression is regulated by production and degradation of mRNAs and proteins, but their specific relationships remain unknown. We combine measurements of protein production and degradation and mRNA dynamics to build a quantitative genomic model of the differential regulation of gene expressio...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-59792 | biostudies-arrayexpress
TranscriptomicsExpression data from RNA half-life experiments in Prochlorococcus
RNA decay was measured in Prochlorococcus after inhibition of transcription by rifampicin using customized Affymetrix gene expression arrays. RNA turnover plays an important role in the gene regulation of microorganisms and influences their speed of acclimation to environmental changes. We investiga...
ORGANISM(S): Prochlorococcus marinus subsp. pastoris str. CCMP1986 
2010-05-16 | E-GEOD-17075 | biostudies-arrayexpress
TranscriptomicsRNA half-life analysis after transcriptional blocking with actinomycin D
Transcriptional profiling of HeLa cells treated with actinomycin D for increasing amounts of time. Relative abundance to control cells was used to estimate the half-life of lncRNAs. Two-condition experiment, actinomycin D-treated vs. untreatted HeLa cells. Biological replicates: 2. Technical replic...
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-62963 | biostudies-arrayexpress
ProteomicsProteome wide measurements of protein half-lives in Mycoplasma pneumoniae
We obtained proteome wide measurements of protein half-lives in M. pneumoniae by performing pulse-chase experiments following SILAC methods. We estimated degradation rates of individual proteins by measuring the increase in light protein compared to heavy protein labeling along the growth curve.
ORGANISM(S): Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
2020-11-24 | PXD016386 | Pride
Degradation rates Protein half-life Silac 
GenomicsmRNA structure regulates protein expression through changes in functional half-life
mRNA structure regulates protein expression through changes in functional half-life
PRJNA578697 | ENA
TranscriptomicsFragmentation of tRNA in Phytophthora infestans asexual life cycle stages and during host plant infection [life cycle]
Background: The oomycete Phytophthora infestans possesses active RNA silencing pathways, which presumably enable this plant pathogen to control the large numbers of transposable elements present in its 240 Mb genome. Small RNAs (sRNAs), central molecules in RNA silencing, are known to also play key ...
ORGANISM(S): Phytophthora infestans 
2014-12-12 | E-GEOD-62674 | biostudies-arrayexpress
TranscriptomicsDynamic profiling of the protein life cycle in response to pathogens (RNA-seq)
Protein expression is regulated by production and degradation of mRNAs and proteins, but their specific relationships remain unknown. We combine measurements of protein production and degradation and mRNA dynamics to build a quantitative genomic model of the differential regulation of gene expressio...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-59784 | biostudies-arrayexpress
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