Protein half-life

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UNIPROT ID/AC

P03034 (1)
P04483 (1)
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1433B_MOUSE (1)
1433E_MOUSE (1)
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CHEBI ID

CHEBI:16027 (2)
CHEBI:17992 (2)
CHEBI:340824 (2)
CHEBI:17148 (2)
CHEBI:15741 (2)
CHEBI:6650 (2)
CHEBI:30746 (2)
CHEBI:17497 (2)
CHEBI:17306 (2)
CHEBI:18012 (2)
CHEBI:30915 (2)
CHEBI:26078 (2)
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CHEBI:28478|CHEBI:17445|CHEBI:18101 (1)
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CHEBI:132960 (1)
CHEBI:167375 (1)
CHEBI:167374 (1)
CHEBI:167373 (1)
CHEBI:167372 (1)
CHEBI:167371 (1)
CHEBI:167370 (1)
CHEBI:36493 (1)
CHEBI:167369 (1)
CHEBI:167368 (1)
CHEBI:167366 (1)
CHEBI:167365 (1)

Metabolite Name

Phosphoric acid (2)
Iberin N-acetyl-cysteine (1)
Fatty Acid Hydroxy-C15:3-GLC (1)
Fatty Acid Dicarboxylic C14:1-GLC (1)
Fatty Acid Hydroxy-C13:1-GLC (1)
Dihydroxyphenyl-gamma-valerolactone-O-sulfate (1)
Cyclohexane carboxylic acid glycine (1)
Cyclohexadiene carboxylic acid glycine (1)
Absicic Acid Glucuronide (1)
Glucose, 1,6-anhydro-, beta- (1)
Sorbitol, 1,5-anhydro- (1)
Inositol, myo- (1)
Phosphoric acid monomethyl ester (1)
Myo-Inositol-phosphate (1)
Mannose-6-phosphate (1)
Glyceric acid-3-phosphate (1)
Sinapic acid, trans- (1)
Pyridine, 3-hydroxy- (1)
Benzaldehyde, 2,5-dihydroxy- (1)
Glutaric acid, 2-oxo- (1)
Glutaric acid, 2-hydroxy- (1)
Benzoic acid, 3,4-dihydroxy- (1)
Gluconic acid-1,5-lactone (1)
Beta-D-Galactopyranoside, 1-isopropyl-, 1-thio- (1)
3,5,11-Eudesmatriene (1)
Selinan (1)
5-Methoxy-4,4,6-trimethyl-7-oxabicyclo[4.1.0]heptan-2-one (1)
8,9-Dehydrothymol methyl ether (1)
Tetrahydrocarvone (1)
2(3H)-Benzofuranone, hexahydro-3a,7a-dimethyl-, cis- (1)

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Modelling Approach

Ordinary differential equation model (3)

Lab affiliation

Cellzome (6)
Department of Biochemistry, University of Oxford (3)
Department of Immunology, College of Basic Medical Science, China Medical University, Shenyang, Liaoning 110122, China (3)
Department of Biochemsitry, University of Oxford (2)
Head, Chair Plant Biotechnology Faculty of Biology University of Freiburg Schaenzlestrasse 1 D-79104 Freiburg Germany (2)
Peking University (2)
University Hospital Cologne (2)
"Mitochondria, Metals and Oxidative Stress" group leader Head "Mass Spectrometry Lab and Proteomics core Facility" Jacques Monod Institute UMR7592 CNRS - Paris Diderot University 15 rue Hélène Brion 75205 Paris Cedex 13, FRANCE tel : 33(1)57278029 (1)
1 URBC, Namur Research Institute for Life Sciences (Narilis), University of Namur (UNamur), 5000, Namur, Belgium (1)
1Department of Chemistry, University of Konstanz, Konstanz, Germany 2Konstanz Resea1Department of Chemistry, University of Konstanz, Konstanz, Germany 2Konstanz Research School-Chemical Biology, University of Konstanz, Konstanz, Germany (1)
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Center for Biomedical Mass Spectrometry, Department of Biochemistry, Boston University School of Medicine (1)
Center for Molecular Medicine, Molecular Cancer Research, University Medical Center Utrecht. Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. (1)
Center for Theragnosis, Korea Institute of Science and Technology, Seoul, Korea (1)
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain (1)
Centre for Targeted Protein Degradation, Dundee, UK (1)
Centro de Biología Molecular "Severo Ochoa" Universidad Autónoma de Madrid, 28049 Madrid, SPAIN (1)
Cheeloo College of Medicine, Shandong University, Jinan 250002, PR.China. Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China. Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei 230001, China. Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei 230001, China. (1)
Cheeloo College of Medicine, Shandong University, Jinan 250002, PR.China. Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China. Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei 230001, China. Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei 230001, China. (1)
Cleveland Clinic (1)
DST/NRF Centre of Excellence in Biomedical Tuberculosis research, SA MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Faculty of Medicine and Health Science, Stellenbosch University, Tygerberg, 7505, Cape Town, South Africa (1)
Departament of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain (1)
Department of Applied Human Sciences, Faculty of Science, and Faculty of Nursing Health Sciences Building, University of Prince Edward Island, Charlottetown, PE, Canada (1)
Department of Biochemistry and Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907 (1)
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Database for mRNA Half-Life of 19,977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse

Degradation of mRNA is one of the key processes that control the steady-state level of gene expression. However, the rate of mRNA decay for the majority of genes is not known. We successfully obtained the rate of mRNA decay for 19 977 non-redundant genes by microarray analysis of RNA samples obtaine...

ORGANISM(S): Mus musculus

2010-05-16 | E-GEOD-13609 | biostudies-arrayexpress

Transcription profiling of human B-cells and mouse NIH-3T3 cells for analysis of RNA synthesis, abundance and decay

This SuperSeries is composed of the following subset Series:; GSE9973: Half-life determination for human B-cells (BL41); GSE9975: newly transcribed RNA (nt-RNA) for IFN alpha and gamma time course; GSE9977: Expression data from NIH-3T3 cells treated with mock, 100 U/ml IFN alpha or 100 U/ml gamma fo...

ORGANISM(S): Homo sapiens

2009-10-10 | E-GEOD-10026 | biostudies-arrayexpress

Expression data from RNA half-life experiments in Prochlorococcus

RNA decay was measured in Prochlorococcus after inhibition of transcription by rifampicin using customized Affymetrix gene expression arrays. RNA turnover plays an important role in the gene regulation of microorganisms and influences their speed of acclimation to environmental changes. We investiga...

ORGANISM(S): Prochlorococcus marinus subsp. pastoris str. CCMP1986

2010-05-16 | E-GEOD-17075 | biostudies-arrayexpress

RNA half-life analysis after transcriptional blocking with actinomycin D

Transcriptional profiling of HeLa cells treated with actinomycin D for increasing amounts of time. Relative abundance to control cells was used to estimate the half-life of lncRNAs. Two-condition experiment, actinomycin D-treated vs. untreatted HeLa cells. Biological replicates: 2. Technical replic...

ORGANISM(S): Homo sapiens

2015-06-30 | E-GEOD-62963 | biostudies-arrayexpress

mRNA structure regulates protein expression through changes in functional half-life

PRJNA578697 | ENA

Changes in mRNA Stability Associated with Cold Stress in Arabidopsis Cells

Control of mRNA half-life is a powerful strategy to adjust individual mRNA levels to various stress conditions, because the mRNA degradation rate controls not only the steady-state mRNA level but also the transition speed of mRNA levels. Here, we analyzed mRNA half-life changes in response to cold s...

ORGANISM(S): Arabidopsis thaliana

2012-12-16 | E-GEOD-31837 | biostudies-arrayexpress

Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models

PRJNA789909 | ENA

Intrinsically disordered segments affect protein half-life in the cell and during evolution.

Not available

S-EPMC4358326 | biostudies-literature

Dynamic profiling of the protein life cycle in response to pathogens (protein)

Protein expression is regulated by production and degradation of mRNAs and proteins, but their specific relationships remain unknown. We combine measurements of protein production and degradation and mRNA dynamics to build a quantitative genomic model of the differential regulation of gene expressio...

ORGANISM(S): Mus musculus

2015-03-06 | E-GEOD-59792 | biostudies-arrayexpress

RNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels

The mammalian RNA-binding protein AUF1 (AU-binding factor 1, also known as heterogeneous nuclear ribonucleoprotein D, hnRNP D) binds to numerous mRNAs and influences their post-transcriptional fate. Given that many AUF1 target mRNAs encode muscle-specific factors, we investigated the function of AU...

ORGANISM(S): Mus musculus

2014-12-22 | E-GEOD-58259 | biostudies-arrayexpress

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