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ProteomicsTomato (Solanum lycopersicum) lysine succinylation LC-MS/MS
Post-translational modification of proteins through lysine succinylation plays important regulatory roles in living cells. Lysine succinylation was recently identified as a novel post-translational modification in several organisms, including Escherichia coli, yeast, Toxoplasma gondii, and HeLa cell...
ORGANISM(S): Alternaria tomato 
2018-10-24 | PXD002380 | Pride
Tomato Lysine succinylation Lc-ms/ms 
ProteomicsLysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation
Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about their scope and cellular distribution. We mapped thousands of succinylation sites in bacteria (E. coli), yeast (S. cerevisiae), human...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2015-06-02 | PXD002277 | Pride
Yeast Human Liver Bacteria Mouse Succinylation Acetylation 
ProteomicsSuccinylation proteome analysis of seedling leaves of Bd21
Protein lysine succinylation, an emerging protein post-translational modification widespread among microbiology, animals and plants, represents an important regulator of cellular processes. In our study, we took the first succinylation proteome analysis in the seedling leaves of Bd21 to draw a schem...
ORGANISM(S): Brachypodium distachyon (Purple false brome) (Trachynia distachya) 
2018-10-26 | PXD003428 | Pride
Succinylation analysis seedling leaves of bd21 
ProteomicsSuccinylome analysis reveals the involvement of lysine succinylation in extreme resistance of Deinococcus radiodurans
Increasing evidences showing that succinylation of lysine residue mainly regulates enzymes involved in the carbon metabolism pathway, both in prokaryotic and eukaryotic cells. Deinococcus radiodurans is one of the most radioresistant organisms on earth, which is famous for its robust resistance. A m...
ORGANISM(S): Deinococcus radiodurans 
2021-04-26 | PXD012149 | Pride
Succinylome  succinylation  dna repair  nucleic acid binding  posttranslational modification 
ProteomicsProteomic Analysis of Lysine Succinylation in oryza sativa
By the combination of affinity enrichment and high-resolution LC-MS/MS analysis, large-scale lysine succinylome analysis was performed. Altogether, 742 lysine succinylation sites in 382 protein groups were identified. Intensive bioinformatic analyses were then carried out to annotate those identifie...
ORGANISM(S): Oryza sativa (Rice) 
2018-10-26 | PXD005582 | Pride
Oryza sativa succinylation 
ProteomicsSystematic Analysis of Lysine Succinylation in Vero cell infected with small ruminant morbillivirus
Small ruminant morbillivirus (SRMV), formerly named Peste-des-petits ruminanats virus (PPRV), belongs to the genus Morbillivirus genus in the family Paramyxoviridae and leads to a highly contagious disease in small ruminants, especially goats and sheep. Lysine succinylation is a newly identified and...
ORGANISM(S): Chlorocebus sabaeus 
2025-05-06 | PXD025025 | Pride
Post-translational modification  lysine succinylation  protein-protein interaction  small ruminant morbillivirus 
MetabolomicsSIRT5 alleviate cardiomyocyte senescence in radiation-induced heart disease via desuccinylation of HADHB

SIRT5 deficiency caused widespread protein hypersuccinylation in cardiac tissue. Succinylation proteomic analysis revealed HADHB as the key SIRT5 target, with lysine 292 (K292) being the dominant succinylation site. Functional studies demonstrated that K292 succinylation impairs HADHB-mediated fa...

2026-03-15 | MTBLS14057 | MetaboLights
ProteomicsProteome-wide lysine succinylome profiling and comprehensive analysis of protein lysine co-modification in developing rice seeds
Lysine succinylation has been recognized as a post-translational modification (PTM) in recent years. It is plausible that succinylation may have a vaster functional impact than acetylation due to bulkier structural changes and greater charge differences on the modified lysine residue. Currently, how...
ORGANISM(S): Oryza sativa (Rice) 
2019-09-09 | PXD013664 | Pride
Post-translational modification  lysine succinylation  succinylome  rice  storage nutrient  seeds 
ProteomicsHuman prostate cancer and Lysine succinylation
: Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men worldwide. Among patients who developed advanced PCa, 80% suffered from bone metastasis, with a sharp drop in the survival rate. Using quantitative global succinylome analysis, we characterized a significant increase of ly...
ORGANISM(S): Homo sapiens (Human) 
2023-06-21 | PXD022005 | Pride
Prostate cancer Lysine succinylation Metastasis 
UnknownImproving protein succinylation sites prediction using embeddings from protein language model.
Not available
S-EPMC9547369 | biostudies-literature
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