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MetabolomicsSeipin Governs Caveolin-1 Trafficking Through Modulating Sphingolipid-Glycerolipid Balance

Dysregulation of Caveolin-1 (CAV1), a key component of caveolae, leads to pleiotropic disorders; yet, the mechanisms controlling its trafficking remain unclear. Here, we show that the lipid droplet (LD) biogenesis factor seipin controls CAV1 localization. Seipin deficiency in mice and HeLa cells ...

2025-07-22 | MTBLS12759 | MetaboLights
MetabolomicsThe patatin-like protein PlpD forms novel structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16-stranded β-barrel transmembrane domain and at least one periplasmic POTRA domain. All previously studied Omp85 proteins promote c...

2025-12-08 | MTBLS9803 | MetaboLights
MetabolomicsCeramide Disrupts TM9SF2-PGK1 Axis to Redirect PD-L1 Trafficking and Enhance Antitumor Immunity

The PD-1/PD-L1 axis represents a cornerstone of cancer immunotherapy, yet the dynamic shuttling of PD-L1 between endosomal recycling and lysosomal degradation routes limits durable responses. Using a CRISPR screen targeting glycosphingolipid metabolism, we identify TM9SF2 as a key regulator of PD...

2026-02-05 | MTBLS13838 | MetaboLights
UnknownAtRMR1 functions as a cargo receptor for protein trafficking to the protein storage vacuole.
Not available
S-EPMC2171354 | biostudies-literature
TranscriptomicsRegulator trafficking on bacterial transcription units in vivo
The in vivo trafficking patterns on DNA by the bacterial regulators of transcript elongation Sigma70, Rho, NusA, and NusG and the explanation for high promoter-proximal levels or peaks of RNA polymerase (RNAP) are unknown. Genome-wide ChIP-chip on E. coli revealed distinct association patterns of r...
ORGANISM(S): Escherichia coli 
2010-05-14 | E-GEOD-13938 | biostudies-arrayexpress
UnknownStructure-function analysis of VPS9-ankyrin-repeat protein (Varp) in the trafficking of tyrosinase-related protein 1 in melanocytes.
Not available
S-EPMC3045006 | biostudies-literature
ProteomicsGlycosylation Limits Forward Trafficking of the Tetraspan Membrane Protein PMP22
Peripheral myelin protein 22 (PMP22) is a tetraspan integral membrane protein for which mistrafficking-causing mutations are linked to the inherited peripheral neuropathy, Charcot-Marie-Tooth disease (CMTD). Wild type (WT) PMP22 is an inefficient folder with ~20% of the protein trafficking to the pl...
ORGANISM(S): Homo sapiens (Human) 
2021-04-27 | PXD023091 | Pride
Charcot-marie-tooth disease Protein quality control Peripheral myelin protein 22 Quantitative proteomics Proteostasis Protein folding 
UnknownVarp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes.
Not available
S-EPMC2695797 | biostudies-literature
GenomicsNKX3-1, a Novel Transcriptional Factor of AR, Promotes Prostate Cancer Cell Survival via RAB3B GTPase-mediated protein trafficking
Androgen receptor (AR) orchestrates an intricate transcriptional regulatory network that governs prostate cancer initiation, development and progression. To understand this network in detail, we generated genome-wide maps of AR occupancy by ChIP-seq in LNCaP cells. We found NKX3-1, an androgen-depen...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-28264 | biostudies-arrayexpress
UnknownProtein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking.
Not available
S-EPMC4652078 | biostudies-literature
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