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MetabolomicsATP-binding Cassette Sub-family C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs
The ubiquitous efflux transporter ATP-binding cassette sub-family C member 5 (ABCC5) is present at high levels in the blood-brain barrier, neurons and glia, but its function is not known. Untargeted metabolomic screens revealed that Abcc5-/- mice accumulate endogenous glutamate conjugates in several...
2015-11-02 | MTBLS197 | MetaboLights
ModelsYoon2017 - Mathematical Modeling of Mutant Transferrin-CRM107 Molecular Conjugates for Cancer Therapy
Mathematical modeling of mutant transferrin-CRM107 molecular conjugates for cancer therapy. Yoon DJ1, Chen KY1, Lopes AM1, Pan AA1, Shiloach J2, Mason AB3, Kamei DT4. Author information 1 Department of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, 5121 Engineering V...
2020-01-09 | MODEL1912160006 | BioModels
ProteomicsEnhanced Characterization of Lysine-Linked Antibody Drug Conjugates Enabled by Middle-Down Mass Spectrometry
HCD Triggered UVPD and EThcD files for characterization of trastuzumab-emtansine (T-DM1)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-03 | MSV000092585 | MassIVE
TranscriptomicsTranscription profiling by array to assess epidemic methicillin-resistant Staphylococcus aureus 16 phenotypes induced by PBD conjugates
Objectives Pyrrolobenzodiazepine (PBD) dimers, tethered through inert propyldioxy or pentyldioxy linkers, possess potent bactericidal activity against a range of Gram-positive bacteria by virtue of their capacity to cross-link duplex DNA in sequence-selective fashion. Here we attempt to improve the ...
ORGANISM(S): Staphylococcus aureus 
2012-04-17 | E-BUGS-118 | biostudies-arrayexpress
ProteomicsLow Density Lipoprotein Receptor Targeting Chimeras for Membrane Protein Degradation and Enhanced Drug Delivery
Antibody-based therapeutics encompass diverse modalities for targeting tumor cells, among which antibody-drug conjugates (ADCs) and extracellular targeted protein degradation (eTPD) specifically depend on efficient lysosomal trafficking for activity. However, many tumor antigens exhibit poor interna...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD064642 | Pride
Antibody based degradation 
ProteomicsProtein mass spectrometry raw data of M7A, M7GA, M7A-DC, and M7GA-DC for DAR calculation in study of MSLN-directed DARPin-drug conjugates
Mesothelin (MSLN) is an attractive therapeutic target for precision cancer treatments. Here, we identify a MSLN-targeting DARPin, M7, which specifically binds to the protease-sensitive C-terminal region of MSLN. Furthermore, we develop two auristatin-based DARPin-drug conjugates (DARPin-DCs), M7A-DC...
ORGANISM(S): Escherichia coli 
2025-09-05 | PXD065630 | Pride
Lc/ms Protein-drug conjugates 
ProteomicsInvestigation of the binding profiles of the dasatinib-oligonucleotide conjugates (0.2, 1 and 5 nM) on Protein Microarrays
Using this approach the dasatinib-oligonucleotide conjugates was applied to planar arrays of >9,000 human proteins spotted in two technical replicates. All proteins in the commercially available ProtoArray® Human Protein MicroArray (Thermo Fisher Scientific) have been purified and arrayed under nati...
ORGANISM(S): synthetic construct 
2022-09-12 | E-MTAB-12192 | biostudies-arrayexpress
ProteomicsCovalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted
Many archetypal and emerging classes of small-molecule therapeutics form covalent 38 protein adducts. In vivo, both the resulting conjugates and their off-target side conjugates have the potential to elicit antibodies, with implications for allergy and drug sequestration. Although β-lactam antibioti...
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2024-08-08 | PXD052026 | Pride
B-lactam Proteomics 
UnknownHijacking Extracellular Targeted Protein Degrader-Drug Conjugates for Enhanced Drug Delivery.
Not available
S-EPMC12576823 | biostudies-literature
UnknownCovalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted.
Not available
S-EPMC11316840 | biostudies-literature
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