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TranscriptomicsMixture models and wavelet transforms reveal high confidence RNA-protein interaction sites in MOV10 PAR-CLIP data
The Photo-Activatable Ribonucleoside-enhanced CrossLinking and ImmunoPrecipitation (PAR-CLIP) method was recently developed for global identification of RNAs interacting with proteins. The strength of this versatile method results from induction of specific T to C transitions at sites of interaction...
ORGANISM(S): Homo sapiens 
2012-08-07 | E-GEOD-37524 | biostudies-arrayexpress
ProteomicsInhibiting Mrt4-rRNA interaction with fumaramidmycin-based derivatives as an unexploited antifungal strategy
The rise of drug resistance and limitations of current antifungal treatments highlight the urgent need for innovative antifungal strategies. Here we present the development of cis-fumaramidmycin-derived analogues as a novel chemotype inhibiting the interactions of ribosome assembly factor Mrt4 with ...
ORGANISM(S): Candida albicans (Yeast) 
2026-04-27 | PXD068797 | Pride
Invasive fungal infections Protein-rna interaction covalent inhibitors Fumaramidmycin derivatives Ribosome assembly factor mrt4 Antifungal target identification 
UnknownFragment-Based Drug Discovery of Novel High-affinity, Selective, and Anti-inflammatory Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction.
Not available
S-EPMC12455397 | biostudies-literature
TranscriptomicsCharacterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling
The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stressors the activity of Nrf2 is inhibited by its interaction with the kelch-like ECH-associated protei...
ORGANISM(S): Mus musculus 
2015-10-31 | E-GEOD-71695 | biostudies-arrayexpress
UnknownUnusual Ni⋯Ni interaction in Ni(ii) complexes as potential inhibitors for the development of new anti-SARS-CoV-2 Omicron drugs.
Not available
S-EPMC10953495 | biostudies-literature
ProteomicsGenetically encoded activity-based ubiquitin and ubiquitin-like protein covalent probes
The nucleophilic thiol-alkyne addition reaction can form a covalent thiovinyl bond with cysteine reactivity specific,as the classical standards for cysteine-reactive warheads in activity-based probes (ABPs).Utilizing this classical reactivity property, we designed two potentially reactive unnatural...
ORGANISM(S): Homo Sapiens 
2025-05-14 | PXD063756 |
TranscriptomicsHNRNPU RNA targets and DNA methylation changes during neural differentiation
This study investigates the molecular mechanisms by which the DNA/RNA-binding protein HNRNPU regulates gene expression during early human neural development. Pathogenic variants in HNRNPU cause a severe neurodevelopmental disorder, but the underlying mechanisms remain poorly understood. To explore t...
ORGANISM(S): Homo sapiens 
2026-02-02 | E-MTAB-14910 | biostudies-arrayexpress
UnknownPotential Novel Thioether-Amide or Guanidine-Linker Class of SARS-CoV-2 Virus RNA-Dependent RNA Polymerase Inhibitors Identified by High-Throughput Virtual Screening Coupled to Free-Energy Calculations.
Not available
S-EPMC8540652 | biostudies-literature
UnknownInhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells.
Not available
S-EPMC8103725 | biostudies-literature
TranscriptomicsNOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation
Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent contribution of epigenetics to the development of this disease. To uncover new synthetic lethalities with known breast cancer oncogenes, we screened an epigenome-focused short hairpin RNA library on a panel...
ORGANISM(S): Homo sapiens 
2014-11-21 | E-GEOD-61727 | biostudies-arrayexpress
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