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ProteomicsProtein aggregation and calcium dysregulation are the earliest hallmarks of familial Parkinson’s disease in human midbrain dopaminergic neurons
Mutations in the SNCA gene cause autosomal dominant Parkinson’s disease (PD), with progressive loss of dopaminergic neurons in the substantia nigra, and accumulation of aggregates of α-synuclein. However, the sequence of molecular events that proceed from the SNCA mutation during development, to its...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035500 | Pride
Dopaminergic neurons Proteomics and parkinsons's disease Hipscs Alpha synuclein 
UnknownA workflow for the integrative transcriptomic description of molecular pathology and the suggestion of normalizing compounds, exemplified by Parkinson's disease.
Not available
S-EPMC5962550 | biostudies-literature
ProteomicsSARS-CoV-2 Infection Impacts Glutamate/Glutamine Metabolism in Syrian Hamster Central Nervous System
Coronaviruses belong to a well-known family of enveloped RNA viruses and the causative agent of the common cold. Although the seasonal coronaviruses do not pose a threat to human life, three members of this family, i.e., SARS-CoV, MERS-CoV and recently, SARS-CoV2, may cause severe acute respiratory ...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2022-09-28 | PXD029426 | Pride
Sars-cov2 Proteomics Glutamine Neuropathology Covid-19 
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