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ProteomicsIntercellular Transmission of a Synthetic Bacterial Cytotoxic Prion-Like Protein in Mammalian Cells.
bacterial amyloidosis, prion-like, RepA-WH1, intercellular transmission,proteotoxic cross-aggregation
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-05-26 | PXD018245 | Pride
Bacterial amyloidosis Repa-wh1 Prion-like Intercellular transmission Proteotoxic cross-aggregation 
ProteomicsCross interactions of Aβ peptides implicated in Alzheimer’s disease shape amyloid oligomer structures and aggregation
A defining hallmark of Alzheimer's disease (AD) is the synaptic aggregation of the amyloid beta (Aβ) peptide. In vivo, Aβ production results in a diverse mixture of variants, of which Aβ40, Aβ42, and Aβ43 are profusely present in the AD brain, and their relative abundance is recognised to play a rol...
ORGANISM(S): Homo sapiens (Human) 
2025-01-31 | PXD057653 | Pride
Amyloid beta Protein aggregation Native ion mobility mass spectrometry 
UnknownA Novel Drosophila Model of Alzheimer's Disease to Study Aβ Proteotoxicity in the Digestive Tract.
Not available
S-EPMC10888607 | biostudies-literature
ProteomicsCompetence-Driven Metabolism Triggers a Protein Aggregation and ROS Loop to Modulate Bacterial Adaptation to Chemical Cationic Biocides
Antibiotic resistance is a growing concern, yet resistance and cross-resistance to widely used chemical biocides are poorly understood. Here, we show that cationic biocides induce V-type ATPase overactivation in Streptococcus gordonii, shifting metabolism to oxidative phosphorylation and increasing ...
ORGANISM(S): Streptococcus Gordonii Str. Challis Substr. Ch1 
PXD077459 |
UnknownThe human HSP70 family of chaperones: where do we stand?
Not available
S-EPMC4837186 | biostudies-literature
UnknownThe aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer's disease.
Not available
S-EPMC12835372 | biostudies-literature
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