Dataset Information

Intercellular Transmission of a Synthetic Bacterial Cytotoxic Prion-Like Protein in Mammalian Cells.

ABSTRACT: bacterial amyloidosis, prion-like, RepA-WH1, intercellular transmission,proteotoxic cross-aggregation

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Cell Culture

SUBMITTER: Vivian de los Rios

LAB HEAD: Rafael Giraldo

PROVIDER: PXD018245 | Pride | 2020-05-26

REPOSITORIES: Pride

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Publications

Intercellular Transmission of a Synthetic Bacterial Cytotoxic Prion-Like Protein in Mammalian Cells.

Revilla-García Aida A Fernández Cristina C Moreno-Del Álamo María M de Los Ríos Vivian V Vorberg Ina M IM Giraldo Rafael R

mBio 20200414 2

RepA is a bacterial protein that builds intracellular amyloid oligomers acting as inhibitory complexes of plasmid DNA replication. When carrying a mutation enhancing its amyloidogenesis (A31V), the N-terminal domain (WH1) generates cytosolic amyloid particles that are inheritable within a bacterial lineage. Such amyloids trigger in bacteria a lethal cascade reminiscent of mitochondrial impairment in human cells affected by neurodegeneration. To fulfill all the criteria to qualify as a prion-like ...[more]

PMID: 32291306

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Dataset Information

Intercellular Transmission of a Synthetic Bacterial Cytotoxic Prion-Like Protein in Mammalian Cells.

Publications

Intercellular Transmission of a Synthetic Bacterial Cytotoxic Prion-Like Protein in Mammalian Cells.

Similar Datasets

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