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MetabolomicsDecoding the Regulatory Networks of Proteus mirabilis Under Succinic Acid Stress: A Multi-Omics Approach

Proteus mirabilis, a key catheter-associated urinary tract infection pathogen that forms antibiotic-resistant crystalline biofilms, was shown via multi-omics analyses to be multimodally inhibited by succinic acid. At 15 mM, succinic acid reduced the bacterium’s growth by 70% and biofilm formation...

2025-09-08 | MTBLS12952 | MetaboLights
TranscriptomicsFunctional redundancy of iron acquisition systems is required for Proteus mirabilis pathogenesis during UTI
Proteus mirabilis is a primary cause of complicated urinary tract infections (UTI). Surprisingly, iron acquisition systems have been poorly characterized in this uropathogen despite the urinary tract being iron-limited. In this report the transcriptome of strain HI4320, cultured under iron limitat...
ORGANISM(S): Proteus mirabilis HI4320 
2010-09-09 | E-GEOD-18051 | biostudies-arrayexpress
TranscriptomicsTranscriptome of Proteus mirabilis in the murine urinary tract
The enteric bacterium Proteus mirabilis is a common cause of complicated urinary tract infections. In the study, microrarrays were used to analyze P. mirabilis gene expression in vivo from experimentally infected mice. Urine was collected at 1, 3, and 7d postinfection, and RNA was isolated from bac...
ORGANISM(S): Proteus mirabilis 
2011-11-29 | E-GEOD-25977 | biostudies-arrayexpress
TranscriptomicsProteus mirabilis mrpJ microarrays
This series of microarrays compares gene expression by the bacterial pathogen Proteus mirabilis when the transcriptional regulator mrpJ is deleted or induced to levels found during experimental urinary tract infection. The enteric bacterium Proteus mirabilis is associated with a significant number ...
ORGANISM(S): Proteus mirabilis HI4320 
2015-04-13 | E-GEOD-63321 | biostudies-arrayexpress
ProteomicsMetabolic interplay between Proteus mirabilis and Enterococcus faecalis facilitates polymicrobial biofilm formation and invasive disease
Catheter-associated urinary tract infections (CAUTI) account for 40% of all nosocomial infections and can lead to significant life-threatening complications such as bacteremia. Microbial biofilms play an important role in the development and pathogenesis of CAUTI, and these biofilms are often polymi...
ORGANISM(S): Proteus mirabilis HI4320 Enterococcus faecalis (Streptococcus faecalis) 
2025-05-06 | PXD041693 | Pride
Ionstar Enterococcus faecalis Proteus mirabilis Quantitative proteomics Biofilm 
TranscriptomicsRole of FliL in Swarmer Cell Differentiation
Proteus mirabilis is an opportunistic pathogen that causes urinary tract infections in immunocompromised patients. Flagellar motility coupled with the ability to differentiate from short swimmer cells to highly elongated swarmer cells constitute key parts of the infection process. The mechanism by w...
ORGANISM(S): Proteus mirabilis 
2011-11-15 | E-GEOD-30810 | biostudies-arrayexpress
GenomicsProteus mirabilis isolate:Proteus mirabilis
Proteus mirabilis isolate:Proteus mirabilis Genome sequencing
PRJNA633229 | ENA
ProteomicsAugmented enterocyte damage during Candida albicans and Proteus mirabilis coinfection
The human gut acts as the main reservoir of microbes and a relevant source of life-threatening infections, especially in immunocompromised patients. There, the opportunistic fungal pathogen Candida albicans adapts to the host environment and additionally interacts with residing bacteria. We investi...
ORGANISM(S): Candida albicans (Yeast) Proteus mirabilis HI4320 
2022-05-09 | PXD031222 | Pride
Candida albicans Proteus mirabilis Enterocytes Coinfection Synergism Cross-kingdom interaction 
GenomicsProteus mirabilis
Proteus mirabilis Genome sequencing
PRJNA647979 | ENA
GenomicsProteus mirabilis
Proteus mirabilis Genome sequencing
PRJNA647951 | ENA
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