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MetabolomicsCysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
Nephropathic cystinosis is a severe monogenic kidney disorder caused by mutations in CTNS, encoding the lysosomal transporter cystinosin, resulting in lysosomal cystine accumulation. The sole treatment, cysteamine, slows down the disease progression, but does not correct the established renal proxim...
2021-06-24 | MTBLS2538 | MetaboLights
MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
MetabolomicsMetabolomic profiling of primary mouse proximal tubule cells (mPTCs) derived from 24-week-old CTR and Atg7 PT-KO kidneys
To explore the role of ATG7 in the kidney PT, we crossed mice homozygous for floxed alleles of Atg7 with Ggt1-Cre mice expressing Cre recombinase under the rat Ggt1 (gamma-glutamyltransferase 1) gene promoter. This generated Atg7fl/fl; γGt1cre/cre mice (hereafter referred to as Atg7 PT-KO), in which...
2026-09-30 | MTBLS15857 | MetaboLights
MetabolomicsHigh-resolution LC-MS/MS lipidomics characterization of wild-type and ATG7-deficient mouse renal proximal tubule cells
This study provides an untargeted lipidomics investigation of ATG7-deficient (cKO) mouse renal proximal tubule cells compared to wild-type (WT) controls to evaluate lipidomic alterations associated with autophagy deficiency. Lipids were extracted from cell culture wells using a single-phase isopropa...
2026-09-30 | MTBLS15861 | MetaboLights
TranscriptomicsProfiling of Transcripts in Rat Proximal Tubule
Freshly isolated rat kidney proximal tubules were subjected for transcript profiling. Three microarray experiments were done to obtain the kidney proxmial tubule transcriptome.
ORGANISM(S): Rattus norvegicus 
2009-01-26 | E-GEOD-13668 | biostudies-arrayexpress
ProteomicsCircadian Gene Expression in Mouse Renal Proximal Tubule
Circadian variability in kidney function has long been recognized but is often ignored as a potential confounding variable in in vivo physiological experiments. To provide a guide for physiological studies on the kidney proximal tubule, we have now created a data resource consisting of expression le...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-10 | PXD039006 | Pride
Circadian variation Proteomics Proximal tubule Transcriptomics 
TranscriptomicsRNA-seq profiling of microdissected rat renal tubule segments
We sequenced mRNAs from glomeruli and 14 different rat renal tubule segments collected by hand microdissection. Collagenase-digested rat renal tubule segments were collected by hand microdissection. Poly(A)-mRNAs were captured from cell lysate and sequenced using paired-end protocol.
ORGANISM(S): Rattus norvegicus 
2015-03-31 | E-GEOD-56743 | biostudies-arrayexpress
TranscriptomicsEffect of GW4064 on primary cultured mouse kidney proximal tubule cells
Global gene expression in the primary cultured mouse kidney proximal tubule cells treated either DMSO or 1uM GW4064 (a FXR agonist) was compared. Results provide insight into mechanisms underlying effects of FXR activation on gene expression in mouse kidney proximal tubule cells. Male C57/BJ mice ag...
ORGANISM(S): Mus musculus 
2015-06-26 | E-GEOD-70296 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Clcn5 knockout in proximal tubules of the kidney
Dent disease has multiple defects attributed to proximal tubule malfunction including low molecular weight proteinuria, aminoaciduria, phosphaturia and glycosuria. In order to understand the changes in kidney function of the Clc5 transporter gene knockout mouse model of Dent disease, we examined gen...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10162 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human renal proximal tube endothelial cells at 24h and 1%oxygen
Aim of the study was to characterize the transcriptional response of human primary renal proximal tubule endothelial cells (RPTEC) to low oxygen stress. Experiment Overall Design: Passage 4 renal proximal tubule epithelial cells were exposed to a humidified atmosphere consisting of either 5% CO2 and...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12792 | biostudies-arrayexpress
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