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MetabolomicsCysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
Nephropathic cystinosis is a severe monogenic kidney disorder caused by mutations in CTNS, encoding the lysosomal transporter cystinosin, resulting in lysosomal cystine accumulation. The sole treatment, cysteamine, slows down the disease progression, but does not correct the established renal proxim...
2021-06-24 | MTBLS2538 | MetaboLights
MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
MetabolomicsImpact of Diabetic Stress Conditions on Renal Cell Metabolome
Diabetic kidney disease is a major complication in diabetes mellitus, and the most common reason for end-stage renal disease. Patients suffering from diabetes mellitus encounter glomerular damage by basement membrane thickening, and develop albuminuria. Subsequently, albuminuria can deteriorate the ...
2019-10-08 | MTBLS1093 | MetaboLights
TranscriptomicsTranscription profiling of human renal proximal tube endothelial cells at 24h and 1%oxygen
Aim of the study was to characterize the transcriptional response of human primary renal proximal tubule endothelial cells (RPTEC) to low oxygen stress. Experiment Overall Design: Passage 4 renal proximal tubule epithelial cells were exposed to a humidified atmosphere consisting of either 5% CO2 and...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12792 | biostudies-arrayexpress
ProteomicsCopper-responsive proteome changes in human kidney proximal tubule epithelial cells
Copper is essential for cellular function but potentially toxic in excess. While copper's influence on cytoskeletal dynamics remains unclear, loss of mechanical integrity is a hallmark of kidney disease. Here we investigated how copper availability modulates mechanical properties and cytoskeletal ar...
ORGANISM(S): Homo sapiens (Human) 
2026-07-21 | PXD072220 | Pride
Proteomics Cytoskeleton Mechanotransduction Actin Kidney Copper Oxidative stress Hk-2 
ProteomicsCircadian Gene Expression in Mouse Renal Proximal Tubule
Circadian variability in kidney function has long been recognized but is often ignored as a potential confounding variable in in vivo physiological experiments. To provide a guide for physiological studies on the kidney proximal tubule, we have now created a data resource consisting of expression le...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-10 | PXD039006 | Pride
Circadian variation Proteomics Proximal tubule Transcriptomics 
ProteomicsProteomics of Rat Proximal-Tubule Cell-Culture Models
Cultured cell lines are widely used for research in the physiology, pathophysiology, toxicology and pharmacology of the renal proximal tubule. The lines that are most appropriate for a given use depend on the genes expressed. New tools for transcriptomic and proteomic profiling using RNA-sequencing ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-10-15 | PXD021160 | Pride
Proximal tubule Kideny Rat 
GenomicsHistone tail modification profiles of human renal tubule epithelial cells
To annotate the regulatory elements in the renal tubule epithelial cells, we profiled 6 histone ChIP-seq in the human kidney epithelical cells (HKC8). We pulled down the DNA with specific antibodies of interests against histone tail modifications in the human rebal tubule epithelial cells. The resul...
ORGANISM(S): Homo sapiens 
2013-08-09 | E-GEOD-49637 | biostudies-arrayexpress
MetabolomicsImproving global feature detectabilities through scan range splitting for untargeted metabolomics by high-performance liquid chromatography-Orbitrap mass spectrometry
Untargeted metabolomics aims at obtaining quantitative information on the highest possible number of low-molecular biomolecules present in a biological sample. Rather small changes in mass spectrometric spectrum acquisition parameters may have a significant influence on the detectabilities of metabo...
2016-06-09 | MTBLS233 | MetaboLights
TranscriptomicsTranscription profiling of human mono or co-cultured HMEC-1 and HK-2 cells to identify the influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells
The effect of the presence of HMEC-1 cells on HK-2 cell gene expression was investigated. Cells were cultured in mono or co-culture on opposite sides of aluminium oxide filters, 0.2 ?µM pore size. These conditions provide a close proximity but not direct contact. RNA from HK-2 cells was assayed with...
ORGANISM(S): Homo sapiens 
2008-02-05 | E-MEXP-1178 | biostudies-arrayexpress
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