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A SILAC-based quantitative affinity purification experiment was performed to study the protein binders of the N-terminal region (1-310) of PRPF40A and its mutated version with the proline-rich sequence substituted by a polyalanine stretch.
ORGANISM(S): Homo sapiens (Human) 
2024-04-08 | PXD046164 | Pride
Conserved role for spliceosomal component PRPF40A in microexon splicing
Microexons (exons ≤30 nts) are important features of neuronal transcriptomes, but pose mechanistic challenges to the splicing machinery. We previously showed that PRP-40, a component of the U1 spliceosome, is globally required for microexon splicing in C. elegans. Here we show that the homologous PR...
ORGANISM(S): Mus musculus 
2024-11-05 | GSE267257 | GEO
Genomics
PRPF40A/B-associated Splicing Events in HL-60
Genomics
PRPF40A coordinates RNA splicing and A-to-I editing to drive/control pancreatic tumor progression and chemoresistance
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