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ProteomicsDNA binding reorganizes the intrinsically disordered C-terminal region of PSC in Drosophila PRC1
Polycomb Group (PcG) proteins regulate gene expression by modifying chromatin. A key PcG complex, PRC1, has two activities: a ubiquitin ligase activity for histone H2A, and a chromatin compacting/nucleosome bridging activity that can inhibit transcription and chromatin remodeling. In Drosophila, the...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2020-05-15 | MSV000085418 | MassIVE
TranscriptomicsSingle cell sequencing of mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis
Mucosal pinch biopsies from ascending, transverse, descending colon and rectum were obtained from ulcerative colitis (UC) and primary sclerosing cholangitis concomitant with colitis (PSC-UC) patients during routine endoscopies and subjected to 5' single-cell RNA sequencing
ORGANISM(S): Homo sapiens 
2026-06-17 | E-MTAB-14955 | biostudies-arrayexpress
TranscriptomicsPSC co-culture day6 11 samples single cell RNA-Seq
The goal of this experiment is to characterize the different cancer associated CAF subtypes that can be induced by tumour-derived signlas in pancreatic stellate cells (PSC). Co-cultures of PSC and tumour organoids were seeded in matrigel and grown for 6 days in basal media. Mono-cultures of PSC were...
ORGANISM(S): Mus musculus 
2025-03-21 | E-MTAB-14944 | biostudies-arrayexpress
TranscriptomicsV(D)J TCR single cell sequencing of mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis
Mucosal pinch biopsies from ascending, transverse, descending colon and rectum were obtained from ulcerative colitis (UC) and primary sclerosing cholangitis concomitant with colitis (PSC-UC) patients during routine endoscopies and subjected to 5' single-cell RNA sequencing with V(D)J TCR analysis
ORGANISM(S): Homo sapiens 
2026-06-17 | E-MTAB-14899 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Pluripotent Stem Cell-Derived Endometrial Stromal Fibroblasts in Monolayer Differentiation and in Co-culture with Endometrial Epithelial Organoids
H9 Pluripotent Stem Cells (PSC) were differentiated to Endometrial Stromal Fibroblasts (PSC-ESF) in monolayer over the course of 12 days. Gene expression was measured at day 0, day 4, day 8, and day 12 of differentiation. At day 12, PSC-ESF were dissociated from monolayer culture for co-culture with...
ORGANISM(S): Homo sapiens 
2021-05-05 | E-MTAB-10375 | biostudies-arrayexpress
TranscriptomicsV(D)J BCR single cell sequencing of mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis
Mucosal pinch biopsies from ascending, transverse, descending colon and rectum were obtained from ulcerative colitis (UC) and primary sclerosing cholangitis concomitant with colitis (PSC-UC) patients during routine endoscopies and subjected to 5' single-cell RNA sequencing with V(D)J BCR analysis
ORGANISM(S): Homo sapiens 
2026-06-17 | E-MTAB-14901 | biostudies-arrayexpress
GenomicsPaenarthrobacter ureafaciens strain:PSC
Paenarthrobacter ureafaciens strain:PSC Genome sequencing
PRJNA1136618 | ENA
TranscriptomicsPSC co-culture time-course 15 samples single cell RNA-sequencing
The goal of this experiment is to characterize the differentiation trajectories of pancreatic stellate cells (PSC) exposed to tumour-derived signals over a 6 days time series. Co-cultures of PSC and tumour organoids were seeded in matrigel and grown for 0-6 days in basal media. Mono-cultures of PSC ...
ORGANISM(S): Mus musculus 
2025-03-21 | E-MTAB-14945 | biostudies-arrayexpress
TranscriptomicsPSC co-culture STING modulation 167 samples bulk RNA-seq
Bulk RNAseq of pancreatic stellate cells (PSC) and tumour cells treated with STING agonist DMXAA, STING inhibitor H151 or DMSO control. PSC were cultured alone as mono-cultures or in co-culture with mouse tumour organoids, The PSC and tumour cells were recovered by FACS using fluorecent proteins mKa...
ORGANISM(S): Mus musculus 
2025-03-19 | E-MTAB-14946 | biostudies-arrayexpress
TranscriptomicsPSC co-culture DMXAA 32 samples IFNg 36 samples bulk RNA-seq
Bulk RNAseq of pancreatic stellate cells (PSC) treated with DMXAA, interferon gamma or DMSO control. PSC were cultured alone as mono-cultures or in co-culture with mouse tumour organoids, The PSC were recovered by FACS using fluorecent protein mKate-2.
ORGANISM(S): Mus musculus 
2025-03-19 | E-MTAB-14943 | biostudies-arrayexpress
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