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MetabolomicsMetabolic Phenotyping and Strain Characterisation of Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients Using Rapid Evaporative Ionisation Mass Spectrometry
Rapid evaporative ionisation mass spectrometry (REIMS) is a novel technique for the real-time analysis of biological material. It works by conducting an electrical current through a sample, causing it to rapidly heat and evaporate, with the analyte containing vapour channelled to a mass spectrometer...
2022-01-26 | MTBLS644 | MetaboLights
MetabolomicsThe patatin-like protein PlpD forms novel structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16-stranded β-barrel transmembrane domain and at least one periplasmic POTRA domain. All previously studied Omp85 proteins promote c...

2025-12-08 | MTBLS9803 | MetaboLights
MetabolomicsThe influence of Pseudomonas aeruginosa infection on the airway metabolome
Pseudomonas aeruginosa is an environmentally resilient bacterium and an important cause of both acute and chronic infections in people with impaired natural barriers or immunological defences. Chronic respiratory infection with P. aeruginosa is a major cause of morbidity and mortality in people with...
2025-11-06 | MTBLS6052 | MetaboLights
MetabolomicsGenome-scale metabolic modelling of responses to polymyxins in Pseudomonas aeruginosa
Background: Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics...
2018-02-28 | MTBLS630 | MetaboLights
MetabolomicsStaphylococcus aureus coagulases increase survival of Pseudomonas aeruginosa during coinfection

Polymicrobial infections involving Staphylococcus aureus are often more severe than single-species infections. S. aureus typically initiates the infection, creating conditions that allow secondary pathogens like Pseudomonas aeruginosa to establish. In this study, we investigate how coagulase prod...

2026-10-16 | MTBLS13310 | MetaboLights
MetabolomicsUntargeted metabolomics reveals species-specific metabolite production and shared nutrient consumption by Pseudomonas aeruginosa and Staphylococcus aureus

While bacterial metabolism is known to impact antibiotic efficacy and virulence, the metabolic capacities of individual microbes in cystic fibrosis lung infections are difficult to disentangle from sputum samples. Here, we show that untargeted metabolomic profiling of supernatants of multiple str...

2021-05-26 | MTBLS2105 | MetaboLights
MetabolomicsComparative metabolomics and transcriptomics revealed multiple pathways associated with polymyxin killing in Pseudomonas aeruginosa
Polymyxins are the last-line antibiotics against multidrug-resistant Pseudomonas aeruginosa however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This study e...
2018-11-14 | MTBLS751 | MetaboLights
MetabolomicsExogenous glutamate potentiates gentamicin to kill multidrug- and carbapenem-resistant Pseudomonas aeruginosa through activating biosynthesis of unsaturated fatty acids

Antibiotic-resistant Pseudomonas aeruginosa is a major clinical challenge due to limited drug uptake. This study shows that exogenous glutamate restores gentamicin efficacy by reprogramming bacterial metabolism to enhance membrane permeability. The effect is mediated through increased biosynthesi...

2025-09-22 | MTBLS12656 | MetaboLights
TranscriptomicsTranscription profiling of Pseudomonas aeruginosa response to low oxygen
In order to understand how Pseudomonas aeruginosa responds to low oxygen we grew strain PAO1 with 3 different oxygen concentrations: 2%, 0.4% and 0% supplemented with nitrate as an electron acceptor. Gene expression under these conditions was compared to that of cells grown with 20% oxygen. Experim...
ORGANISM(S): Pseudomonas aeruginosa 
2008-06-15 | E-GEOD-6741 | biostudies-arrayexpress
no omics definedGenotyping of twenty Pseudomonas aeruginosa strains
20 P. aeruginosa strains were genotyped using a custom spotted oligo array (Ausubel P. aruginosa genotyping 4.8K v1), which included primarily oligos for genes present in strain PA14 but absent in PAO1, and oligos for genes present in PAO1 but absent in PA14 (as well as controls).
ORGANISM(S): Pseudomonas aeruginosa 
2006-10-06 | E-MEXP-824 | biostudies-arrayexpress
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