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MetabolomicsPseudorabies Virus Triggers Ferritinophagy-Mediated Ferroptosis and Neuroinflammation in Viral Encephalitis

Pseudorabies virus (PRV), a member of the Alphaherpesvirinae subfamily, primarily infects pigs and poses a significant threat to the swine industry. In recent years, emerging PRV variants have been reported to infect humans, predominantly causing encephalitis. Ferroptosis is a recently identified...

2026-04-17 | MTBLS12373 | MetaboLights
MetabolomicsResearch on vaccine immunity based on gut microbiota and metabolomics The impact of pseudorabies virus infection

Pseudorabies virus infection causes intestinal flora disorder in animals, leading to diarrhea. To explore the effect of inactivated pseudorabies vaccine immunization on pseudorabies virus infection, this study sequenced the serum metabolome and intestinal microbiota of Hu sheep, analyzed their di...

2025-09-03 | MTBLS12933 | MetaboLights
MetabolomicsResearch on vaccine immunity based on gut microbiota and metabolomics The impact of pseudorabies virus infection

Pseudorabies virus infection causes intestinal flora disorder in animals, leading to diarrhea. To explore the effect of inactivated pseudorabies vaccine immunization on pseudorabies virus infection, this study sequenced the serum metabolome and intestinal microbiota of Hu sheep, analyzed their di...

2025-09-04 | MTBLS12936 | MetaboLights
TranscriptomicsTranscription profiling of pig brain and lung to natural infection by Pseudorabies virus
Six piglets (age 2-4 days) suffering from pseudorabies virus were identified during at outbreak at a commercial farm. RNA was extracted from lung (n=4) and brain (n=6) of the infected pigs, and compared to lung/brain RNA from a control pool of three uninfected piglets. Expression profiling used a ...
ORGANISM(S): Sus scrofa 
2009-10-02 | E-MEXP-2376 | biostudies-arrayexpress
TranscriptomicsEffects of Pseudorabies Virus Infection on the Tracheobronchial Lymph Node Transcriptome
RNA isolated from draining tracheobronchial lymph nodes (TBLN) from 5-week old pigs, either clinically infected with a feral isolate of Pseudorabies virus or uninfected were interrogated using Illumina Digital Gene Expression Tag Profiling. Over 100 million tag sequences were observed, representing ...
ORGANISM(S): Sus scrofa domesticus 
2015-10-30 | E-GEOD-74473 | biostudies-arrayexpress
ProteomicsAn unbiased approach to mapping the signaling network of the pseudorabies virus US3 protein
The US3 serine/threonine protein kinase is conserved among the alphaherpesvirus family and represents an important virulence factor. US3 plays a role in viral nuclear egress, induces dramatic alterations of the cytoskeleton, represses apoptosis, enhances gene expression and modulates the immune resp...
ORGANISM(S): Sus scrofa (Pig) 
2020-11-24 | PXD021751 | Pride
Alphaherpesvirus Pseudorabies virus Phosphoproteome Us3 Kinase Prv 
ProteomicsiTRAQ-based phospho-proteomics identifies a critical role of ATF2 in pseudorabies virus replication
Pseudorabies virus (PRV), the etiological agent of Aujeszky’s disease, is a swine pathogen of the alphaherpesvirinae subfamily resulting in devastating neurological and respiratory disorders in piglets, or abortion in pregnant sows.Here, we performed isobaric tags for relative and absolute quantitat...
ORGANISM(S): Bos taurus (Bovine) 
2022-10-13 | PXD014685 | Pride
Pseudorabies virus Phosphorylation Itraq Atf2 
GenomicsPseudorabies virus transcriptome sequencing
Characterization of pseudorabies virus transcriptome by Illumina sequencing
PRJEB9526 | ENA
ProteomicsThe axonal sorting activity of pseudorabies virus Us9 protein depends on the state of neuronal maturation The axonal sorting activity of pseudorabies virus Us9 protein depends on the state of neuronal maturation
Alpha-herpesviruses establish a life-long infection in the nervous system of the affected host; while this infection is restricted to peripheral neurons in a heathy host, it can spread within the neuronal circuitry in compromised individuals leading to adverse health consequences. Pseudorabies viru...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-01-04 | PXD017822 | Pride
Virus-host Tmt Ip-ms Lfq Us9 Prv Dda 
TranscriptomicsEffects of Pseudorabies Virus Infection on the Tracheobronchial Lymph Node Transcriptome
RNA isolated from draining tracheobronchial lymph nodes (TBLN) from 5-week old pigs, either clinically infected with a feral isolate of Pseudorabies virus or uninfected were interrogated using Illumina Digital Gene Expression Tag Profiling. Over 100 million tag sequences were observed, representing ...
ORGANISM(S): Sus scrofa domesticus 
2015-10-30 | GSE74473 | GEO
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