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ProteomicsPseudouridylation of tRNA-derived fragments steers translational control in stem cells
Pseudouridylation (Ψ) is the most abundant and widespread type of RNA epigenetic modification in living organisms; however, the biological role of Ψ remains poorly understood. Here, we show that a Ψ-driven posttranscriptional program steers translation control to impact stem cell commitment during e...
ORGANISM(S): Homo sapiens (Human) 
2018-04-11 | PXD008676 | Pride
Dimethyl labelling Trna Pseudouridylation 
TranscriptomicsChemical Pull-Down Reveals Comprehensive and Dynamic Pseudouridylation in Mammalian Transcriptome
Pseudouridine (Ψ) is the most abundant RNA modification, yet little is known about its content, dynamics and function in mRNA and ncRNA. Here, we perform quantitative MS analysis and develop CAP-seq for transcriptome-wide Ψ profiling. The unexpected high Ψ content (Ψ/U ratio: ~ 0.2% to 0.6%) indicat...
ORGANISM(S): Mus musculus 
2015-06-05 | E-GEOD-63655 | biostudies-arrayexpress
TranscriptomicsPseudouridylation in Naf1+/- mice
Pseudo-seq was used to measure differences in the extent of pseudouridine (Ψ) modification in rRNA from mice haploinsufficient for the H/ACA biogenesis factor Naf1 compared to wild- type. We measured telomerase RNA levels as well as a sample of box H/ACA RNAs and found they were all decreased in Na...
ORGANISM(S): Mus musculus 
2016-08-07 | E-GEOD-78063 | biostudies-arrayexpress
TranscriptomicsPSI-seq to Identify Sites of Pseudouridylation in S. cerevisiae
Using a technique based on the ability of CMC to specifically label pseudouridines and to stop reverse transcriptase, we provide a transcriptome-wide map of pseudouridylation in S. cerevisiae under log phase and heat shock conditions 4 conditions: log phase (2x), heat shock, and stationary phase. Fo...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-24 | E-GEOD-60445 | biostudies-arrayexpress
UnknownGuide RNA acrobatics: positioning consecutive uridines for pseudouridylation by H/ACA pseudouridylation loops with dual guide capacity.
Not available
S-EPMC8763049 | biostudies-literature
GenomicsPseudouridylation of 7SK by PUS7 regulates Pol II transcription elongation
Pseudouridylation of 7SK by PUS7 regulates Pol II transcription elongation
PRJNA1216229 | ENA
UnknownControl of protein synthesis through mRNA pseudouridylation by dyskerin.
Not available
S-EPMC10381945 | biostudies-literature
UnknownHuman box H/ACA pseudouridylation guide RNA machinery.
Not available
S-EPMC480876 | biostudies-literature
UnknownCharacterizing RNA Pseudouridylation by Convolutional Neural Networks.
Not available
S-EPMC9170758 | biostudies-literature
UnknownRegulation and Function of RNA Pseudouridylation in Human Cells.
Not available
S-EPMC8007080 | biostudies-literature
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