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TranscriptomicsGene expression in psoriasis lesions and uninvolved skin
Psoriasis is a chronic inflammatory skin disease characterized by marked proliferation of keratinocytes leading to pronounced epidermal hyperplasia, elongation of rete ridges and hyperkeratosis. The most common form of psoriasis, chronic plaque psoriasis (Psoriasis vulgaris), involves relatively sta...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-50790 | biostudies-arrayexpress
TranscriptomicsExpression data from skin biopsy samples from patients with moderate-to-severe psoriasis
A gene expression profiling sub-study was conducted in which skin biopsy samples were collected from 85 patients with moderate-to-severe psoriasis who were participating in ACCEPT, an IRB-approved Phase 3, multicenter, randomized trial. This analysis identified 4,175 probe-sets as being significantl...
ORGANISM(S): Homo sapiens 
2012-07-25 | E-GEOD-30999 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human response to etanercept treatment in patients with Psoriasis
The success of TNF inhibitors for treatment of psoriasis and other inflammatory diseases was previously attributed to blockade of innate immunity. In a clinical trial using etanercept TNF blocking agent to treat psoriasis vulgaris, we used affymetrix gene arrays to analyze broad gene profiles in le...
ORGANISM(S): Homo sapiens 
2009-11-09 | E-GEOD-11903 | biostudies-arrayexpress
GenomicsOptimizing single-cell transcriptomic discrimination of atopic dermatitis versus psoriasis vulgaris
Optimizing single-cell transcriptomic discrimination of atopic dermatitis versus psoriasis vulgaris
EGAS00001007487 | EGA
TranscriptomicsTranscriptome of inflammatory myeloid DCs in psoriasis
Background: Previous work has identified CD11c+CD1c- dendritic cells (DCs) as the major 'inflammatory' dermal DC population in psoriasis vulgaris and CD1c+ DCs as the 'resident' cutaneous DC population. Objective: To further define molecular differences between these two myeloid dermal DC populatio...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-20264 | biostudies-arrayexpress
TranscriptomicsIL-17A is an essential cytokine to sustain pathogenic cell activation and inflammatory gene circuits in psoriasis vulgaris
In psoriasis, inflammation and epidermal hyperplasia are thought to be controlled by T cell-derived cytokines. Evidence now suggests that Th17 and Th22 cells infiltrate psoriasis lesions and by secreting IL-17 and IL-22, respectively, may drive disease-specific gene or cell responses. While studies ...
ORGANISM(S): Homo sapiens 
2012-01-31 | E-GEOD-31652 | biostudies-arrayexpress
GenomicsDNA Methylation Profile in Psoriasis Vulgaris and Generalized Pustular Psoriasis Patients
DNA Methylation Profile in Psoriasis Vulgaris and Generalized Pustular Psoriasis Patients
PRJNA1303214 | ENA
ModelsFelixGarza2017 - Blue Light Treatment of Psoriasis (simplified)
FelixGarza2017 - Blue Light Treatment of Psoriasis (simplified) This model is described in the article: A Dynamic Model for Prediction of Psoriasis Management by Blue Light Irradiation. Félix Garza ZC, Liebmann J, Born M, Hilbers PA, van Riel NA. Front Physiol 2017; 8: 28 ...
2024-09-02 | BIOMD0000000695 | BioModels
Methylation profilingDNA Methylation Profile in Psoriasis Vulgaris and Generalized Pustular Psoriasis Patients
Epigenetics plays a role in the pathogenesis of psoriasis vulgaris and generalized pustular psoriasis (GPP) through DNA methylation modifications that cause changes in immune responses. Psoriasis vulgaris is dominated by autoimmune responses, driven by Th17 cells producing IL-17, whereas GPP is domi...
ORGANISM(S): Homo sapiens 
2025-08-07 | GSE304903 | GEO
TranscriptomicsBased on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris
There is a controversy surrounding the existence of palmoplantar pustulosis (PPP) and palmoplantar pustular psoriasis (PPPP) as separate clinical entities or as variants of the same clinical entity. We used gene expression microarray to compare gene expression in PPP and PPPP. PPP and PPPP could not...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-80047 | biostudies-arrayexpress
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