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MetabolomicsNutritional Psychiatric Illness Studies
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ORGANISM(S): Homo sapiens 
ST000664 | MetabolomicsWorkbench
MetabolomicsHuman Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically-developing (TD) and ASD individuals, though it remains unclear whether the microbiome contrib...
2019-07-04 | MTBLS726 | MetaboLights
MetabolomicsAkkermansia muciniphila attenuates obsessive-compulsive disorder-like behavior by producing L-tyrosine
Obsessive-compulsive disorder (OCD) ranks among the most prevalent psychiatric disorders globally. The impact of the gut microbiota and associated metabolites on OCD remains unclear. Here, we report a remarkable reduction of Akkermansia muciniphila (A. muciniphila) abundance in both patients and mic...
2026-08-20 | MTBLS10141 | MetaboLights
MetabolomicsAkkermansia muciniphila attenuates obsessive-compulsive disorder-like behavior by producing L-tyrosine

Obsessive-compulsive disorder (OCD) ranks among the most prevalent psychiatric disorders globally. The impact of the gut microbiota and associated metabolites on OCD remains unclear. Here, we report a remarkable reduction of Akkermansia muciniphila (A. muciniphila) abundance in both patients and ...

2026-08-20 | MTBLS10145 | MetaboLights
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls
This SuperSeries is composed of the following subset Series:; GSE5388: Adult postmortem brain tissue (dorsolateral prefrontal cortex) in subjects with bipolar disorder; GSE5389: Adult postmortem brain tissue (ortibtofrontal cortex) in subjects with bipolar disorder; Bipolar affective disorder is a s...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5392 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human brain tissue from subjects with bipolar disorder and healthy controls
Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefro...
ORGANISM(S): Homo sapiens 
2007-06-24 | E-GEOD-5388 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human post-mortem brain tissue (orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls
Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (orbitofrontal corte...
ORGANISM(S): Homo sapiens 
2007-07-03 | E-GEOD-5389 | biostudies-arrayexpress
ProteomicsParallel reaction monitoring (PRM) in adolescent patients with psychiatric disorders: Major Depressive Disorder, Bipolar Disorder, and Schizophrenia
This dataset includes PRM-based plasma proteomics from adolescent patients diagnosed with Major Depressive Disorder (MDD), Bipolar Disorder (BD), and Schizophrenia (SZ), as well as healthy controls. The study aims to identify differentially expressed proteins and potential circulating biomarkers acr...
ORGANISM(S): Homo Sapiens 
PXD065610 |
TranscriptomicsGenetic Neuropathology of Obsessive Psychiatric Syndromes
Anorexia nervosa (AN), bulimia nervosa (BN), and obsessive-compulsive disorder (OCD) are complex psychiatric disorders with shared obsessive features, thought to arise from the interaction of multiple genes of small effect with environmental factors. Potential candidate genes for AN, BN, and OCD ha...
ORGANISM(S): Homo sapiens 
2014-08-08 | E-GEOD-60190 | biostudies-arrayexpress
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