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TranscriptomicsThe ShcA PTB Domain Functions as a Biological Sensor of Phospho-tyrosine Signaling During Breast Cancer Progression
The ShcA adaptor possesses two phosphotyrosine binding motifs, which include an SH2 and a PTB domain. In the majority of cases, ShcA utilizes its PTB domain to engage activated receptor tyrosine kinases (RTKs). To establish the mportance of this domain during mammary tumorigenesis, we employed a Sh...
ORGANISM(S): Mus musculus 
2013-08-07 | E-GEOD-41718 | biostudies-arrayexpress
TranscriptomicsQuaking is a global regulator of muscle-specific alternative splicing in vertebrates [siRNA data]
This work provides the first evidence that Qk is a global regulator of splicing in vertebrates, defines a new splicing regulatory network in muscle, and suggests that overlapping splicing networks contribute to the complexity of changes in alternative splicing during differentiation. Alternative spl...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-40961 | biostudies-arrayexpress
TranscriptomicsDirect Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated microRNA Circuits
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell lineage-specific transcription factors. Here we report that repression of a single RNA binding protein PTB, which occurs during normal brain development via the action of miR-124, is s...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-GEOD-42701 | biostudies-arrayexpress
TranscriptomicsQuaking is a global regulator of muscle-specific alternative splicing in vertebrates [differentiation data]
This work provides the first evidence that Qk is a global regulator of splicing in vertebrates, defines a new splicing regulatory network in muscle, and suggests that overlapping splicing networks contribute to the complexity of changes in alternative splicing during differentiation. Alternative spl...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-40956 | biostudies-arrayexpress
UnknownRedefining PTB domain into independently functional dual cores.
Not available
S-EPMC7301631 | biostudies-literature
TranscriptomicsThe ShcA PTB Domain Functions as a Biological Sensor of Phospho-tyrosine Signaling During Breast Cancer Progression
The ShcA adaptor possesses two phosphotyrosine binding motifs, which include an SH2 and a PTB domain. In the majority of cases, ShcA utilizes its PTB domain to engage activated receptor tyrosine kinases (RTKs). To establish the mportance of this domain during mammary tumorigenesis, we employed a Shc...
ORGANISM(S): Mus musculus 
2013-08-07 | GSE41718 | GEO
TranscriptomicsQuaking is a global regulator of muscle-specific alternative splicing in vertebrates
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-40962 | biostudies-arrayexpress
UnknownStructural insights into FRS2α PTB domain recognition by neurotrophin receptor TrkB.
Not available
S-EPMC4057350 | biostudies-literature
UnknownStructural basis of SNT PTB domain interactions with distinct neurotrophic receptors.
Not available
S-EPMC5155437 | biostudies-literature
UnknownScreening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays.
Not available
S-EPMC1636785 | biostudies-literature
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