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TranscriptomicsPTP1B deficiency effect on mammary gland development and differentiation
Analysis of protein tyrosine phosphatase 1B (PTP1B) deficient mammary glands from nulliparous mice at estrous and pregnancy day 3, 7, 10 and 15. We used a genetically ablated PTP1B mouse model to gain a deeper knowledge of the role PTP1B plays in mammary gland development and to define the mechanism...
ORGANISM(S): Mus musculus 
2012-10-23 | E-GEOD-41768 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of IL-10 treatment of wildtype and Ptpn1-/- knockout peritoneal macrophages
We report here the deep sequencing of the mRNA from peritoneal exudate cells (macrophages) purified from wildtype or Ptpn1 (PTP1B) knockout mice, either treated or untreated with IL-10. In periotenal macrophages IL-10 activates the transcription factor STAT3 to execute and anti-inflammatory gene exp...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-49449 | biostudies-arrayexpress
ProteomicsQuantitative Proteomics Identifies Protein Tyrosine Phosphatase 1B as Modulator of B Cell Antigen Receptor Signaling
B cell antigen receptor (BCR) signaling is initiated by protein kinases and limited by counteracting phosphatases that currently are less well studied in their regulation of BCR signaling. We here used the B cell line Ramos to identify and quantify human B cell signaling components. Specifically, a ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD024086 | Pride
Ramos b cells Ptp1b Bcr signaling Co-ip Silac Substrate trapping 
ProteomicsPTP1B Deficiency in Myeloid Cells Increases Susceptibility to Candida albicans Infection by Modulating Anti-fungal Immunity
Invasive candidiasis is a serious healthcare problem with high mortality rates, particularly in immunocompromised patients. Understanding how the immune response towards Candida albicans is mounted and controlled is fundamental to developing new therapeutic strategies. Protein tyrosine phosphatase 1...
ORGANISM(S): Candida albicans (Yeast) Mus musculus (Mouse) 
2025-08-28 | PXD057300 | Pride
Ptp1b Fungal infection Myeloid cell 
GenomicsThe effect of PTP1B inhibitor (MSI-1436) on neutrophils.
The effect of PTP1B inhibitor (MSI-1436) on neutrophils.
PRJNA763548 | ENA
GenomicsCardiac miRNA profiling during pressure overload-induced hypertrophy in PTP1B-deficient mice
Cardiac miRNA profiling during pressure overload-induced hypertrophy in PTP1B-deficient mice
PRJNA821470 | ENA
TranscriptomicsPTP1B deficiency effect on mammary gland development and differentiation
Analysis of protein tyrosine phosphatase 1B (PTP1B) deficient mammary glands from nulliparous mice at estrous and pregnancy day 3, 7, 10 and 15. We used a genetically ablated PTP1B mouse model to gain a deeper knowledge of the role PTP1B plays in mammary gland development and to define the mechanism...
ORGANISM(S): Mus musculus 
2012-10-23 | GSE41768 | GEO
GenomicsPTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling
PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling
PRJNA1398868 | ENA
TranscriptomicsThe effect of PTP1B inhibitor (MSI-1436) on neutrophils.
Acute Lung Injury (ALI) can cause Acute Respiratory Distress Syndrome (ARDS), a lethal condition with limited treatment options and currently a common global cause of death due to COVID-19-induced ALI. ARDS secondary to Transfusion-Related Acute Lung Injury (TRALI) has been recapitulated pre-clinica...
ORGANISM(S): Mus musculus 
2021-09-18 | GSE184197 | GEO
GenomicsEffect of olanzapine and aripiprazole supplemented diet treatments on gene expression of WT and PTP1B KO mice liver
Effect of olanzapine and aripiprazole supplemented diet treatments on gene expression of WT and PTP1B KO mice liver
PRJNA923038 | ENA
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