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ProteomicsPharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis
Protein tyrosine phosphatase mitochondrial 1 (PTPMT1), is a member of the protein tyrosine phosphatase superfamily localized on the mitochondrial inner membrane, and regulates the biosynthesis of cardiolipin. Given the important position of PTPMT1 in mitochondrial function and metabolism, pharmacolo...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058606 | Pride
Ptpmt1  mitochondria  ferroptosis  tca cycle  hepatocellular carcinoma 
GenomicsEffect of PTPMT1 deficiency on regulatory T cells
Effect of PTPMT1 deficiency on regulatory T cells
PRJNA1219111 | ENA
UnknownPharmacological targeting of the mitochondrial phosphatase PTPMT1.
Not available
S-EPMC2872949 | biostudies-literature
GenomicsPTPMT1-dependent regulatory T cells mediate immunological tolerance to gut pathobionts
PTPMT1-dependent regulatory T cells mediate immunological tolerance to gut pathobionts
PRJNA1218772 | ENA
UnknownDrosophila PTPMT1 Has a Function in Tracheal Air Filling.
Not available
S-EPMC7334580 | biostudies-literature
GenomicsPTPMT1 is critical for both expansion and differentiation of activated CD8 T cells
PTPMT1 is critical for both expansion and differentiation of activated CD8 T cells
PRJNA894154 | ENA
ProteomicsProteomic dataset of Wt, PTPMT1 KO, CHOP KO and PTPMT1 CHOP double KO regulatory T cells
Mitochondrial defects are emerging as key drivers of gut inflammation, colitis, and IBD. Yet, their role in regulating immune tolerance, fine-tuned by helper T cells, is unclear. Understanding how metabolic changes in T cells impact gut tolerogenic mechanisms, including gut colonization and the bal...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-14 | PXD071483 | Pride
Ptpmt1 Treg Cardiolipin 
UnknownPharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis.
Not available
S-EPMC11973169 | biostudies-literature
UnknownStructural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.
Not available
S-EPMC3142007 | biostudies-literature
TranscriptomicsPTPMT1 is critical for both expansion and differentiation of activated CD8 T cells
To understand the function of PTPMT1 in CD8 T cells responses, we characterized the transcriptomes of activated CD8+ T cells from PTPMT1 wildtype and knockout mice
ORGANISM(S): Mus musculus 
2023-11-21 | GSE216523 | GEO
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