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GenomicsTargeting PTPRK-RSPO3 tumors
Targeting PTPRK-RSPO3 colon tumors.
PRJEB10684 | ENA
ProteomicsQuantitative tyrosine phosphoproteomics of wild type and PTPRK KO tumour xenografts
TMT-based quantitation of tyrosine phosphoproteomes of wild type and PTPRK KO tumour xenografts to determine additional mechanisms of tumour suppression by receptor tyrosine phosphatase PTPRK
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD050617 | Pride
Tmt Phosphatase Ptprk Tyrosine phosphoproteomics Tumour xenografts 
ProteomicsThe homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion
Cell-cell communication in multicellular organisms depends on the dynamic and reversible phosphorylation of protein tyrosine residues. The receptor-linked protein tyrosine phosphatases (RPTPs) receive cues from the extracellular environment and are well placed to influence cell signaling. However, t...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD013055 | Pride
Phosphorylation  silac 
GenomicsThe receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumor suppression
The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumor suppression
PRJNA1068645 | ENA
TranscriptomicsThe receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumor suppression
PTPRK is a receptor tyrosine phosphatase linked to the regulation of growth factor signalling and tumor suppression. It is stabilized at the plasma membrane by trans homophilic interactions upon cell-cell contact. It regulates cell-cell adhesion, but is also reported to regulate numerous cancer-asso...
ORGANISM(S): Homo sapiens Mus musculus 
2024-07-02 | GSE254156 | GEO
ProteomicsProtein tyrosine phosphatase receptor kappa regulates glycolysis, de novo lipogenesis and promotes hepatocyte metabolic reprogramming in obesity.
Fat accumulation, de novo lipogenesis, and glycolysis are key contributors to hepatocyte reprogramming and the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). The molecular mechanisms affected by steatosis and inflammation in the obese states remain unknown. Here we...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-21 | PXD046506 | Pride
Masld Obesity Phosphoproteomic Liver Ptprk 
GenomicsRNA-sequencing in for Low, high or high density+PTPRK-deleted HeLa cells
RNA-sequencing in for Low, high or high density+PTPRK-deleted HeLa cells
PRJNA875279 | ENA
UnknownThe receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumour suppression.
Not available
S-EPMC11298714 | biostudies-literature
TranscriptomicsRNA-sequencing in for Low, high or high density+PTPRK-deleted HeLa cells
Density-dependent regulation of cell growth is presumed to be caused by cell-cell contact, but the underlying molecular mechanism is not yet clearly defined. Our goal is to identify receptor-type protein tyrosine phosphatase-kappa (PTPRK) is an important regulator of cell contact-dependent growth in...
ORGANISM(S): Homo sapiens 
2022-09-02 | GSE212324 | GEO
UnknownPTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity.
Not available
S-EPMC11535053 | biostudies-literature
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