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TranscriptomicsINDUCED HYPER (T3) AND HYPO (PTU) THYROIDISM AFFECT TRANSCRIT PROFILE IMMUNE RESPONSES IN RAINBOW TROUT HEAD KIDNEY
In mammals, increasing data suggests that there exists a complex and bi-directional relationship between thyroid and immune systems. However the existence of such interactions in fish is unknown. Here, we administered the biologically active hormone 3.3â?².5-triiodo-L-thyronine (T3) and the anti-thy...
ORGANISM(S): Oncorhynchus mykiss 
2016-07-03 | E-GEOD-54422 | biostudies-arrayexpress
Unknown1-phenyl 2-thiourea (PTU) activates autophagy in zebrafish embryos.
Not available
S-EPMC8143244 | biostudies-literature
GenomicsTranscriptional profile of zebrafish eyes after exposure to 350 mg/L Propylthiouracyl (PTU)
Transcriptional profile of zebrafish eyes after exposure to 350 mg/L Propylthiouracyl (PTU)
PRJNA497083 | ENA
TranscriptomicsTranscription profiling of mouse cerebella from pups exposed to PTU to induce hypothyroidism
Pregnant dams were treated with 0.1% or 0.04% 6-propyl-2-thiouracil (PTU) in drinking water continuously from day 13 post conception until weaning to produce hypothyroid pups. Cerebella were collected from vehicle and 0.1% PTU treated pups at post-natal day (PND) 15 and mRNA from these was subjected...
ORGANISM(S): Mus musculus 
2008-05-02 | E-MEXP-1048 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from hypothyroid mice pups produced from dams given 6-propyl-2-thiouracil (PTU) in their drinking water
Pregnant dams were treated with 0.1% or 0.04% 6-propyl-2-thiouracil (PTU) in drinking water continuously from day 13 post conception until weaning to produce hypothyroid pups. livers were collected from vehicle and 0.1% PTU treated pups at post-natal day (PND) 15 and mRNA from these was subjected to...
ORGANISM(S): Mus musculus 
2007-05-03 | E-MEXP-1091 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of zebrafish eyes after exposure to 350 mg/L Propylthiouracyl (PTU)
Vertebrate eye devlopment is partially regulated by thyroid hormones. Propylthiouracyl is a pharmaceutical that lowers thyroid hormone levels. We investigated the effects of PTU on eye development of zebrafish. We expected PTU exposure to cause transcriptional changes of visual-system-related genes,...
ORGANISM(S): Danio rerio 
2019-05-09 | GSE121334 | GEO
TranscriptomicsAkt1 is critical in Maintaining the Blood-Testis Barrier Following Exposure to the Neonatal Goitrogen, 6-N-Propylthiouracil (PTU)
Akt1 plays a protective role in the postnatal C57BL6 mouse testis following lactational exposure to the neonatal goitrogen, propylthiouracil (PTU). To elucidate the transcriptional profile mediating this phenotypic effect, we monitored changes in testicular gene expression at postnatal days (PNDs) 1...
ORGANISM(S): Mus musculus 
2011-09-04 | GSE28664 | GEO
UnknownReduced hippocampal brain-derived neurotrophic factor (BDNF) in neonatal rats after prenatal exposure to propylthiouracil (PTU).
Not available
S-EPMC3384077 | biostudies-literature
GenomicsPrzewalskia tangutica isolate:leaf-Ptu-Hic
Przewalskia tangutica isolate:leaf-Ptu-Hic Genome sequencing and assembly
PRJNA791792 | ENA
GenomicsCharacterizing the TRb1 cistrome in mouse liver
ChIP-seq data from mouse liver over-expressing GFP and fed a PTU diet and treated with saline, or overexpressing biotinylated TRb1 and GFP and fed a PTU diet, treated with either saline or T3 Mouse liver was infected with adenovirus that either expressed only GFP or GFP and biotinylated TRb1 and wer...
ORGANISM(S): Mus musculus 
2013-12-18 | E-GEOD-52613 | biostudies-arrayexpress
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