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TranscriptomicsPU.1 regulates T-lineage gene expression and progression via indirect repression during early T-cell development
The Ets family transcription factor PU.1 is essential for the development and maintenance of several hematopoietic lineages. In the thymus, PU.1 is expressed only in the early ETP/DN1, DN2a and DN2b stages of development. While PU.1 deletion in multipotent precursors leads to a complete block in T-c...
ORGANISM(S): Mus musculus 
2015-04-08 | E-GEOD-65344 | biostudies-arrayexpress
TranscriptomicsIdentification of PU.1 target genes by expression profiling of PUER cells
PU.1 is a key transcription factor for macrophage differentiation. Novel PU.1 target genes were identified by mRNA profiling of PU.1-deficient progenitor cells (PUER) before and after PU.1 activation. We used two different types of Affymetrix DNA-microarrays (430 2.0 arrays and ST 1.0 exon arrays) t...
ORGANISM(S): Mus musculus 
2008-10-11 | E-GEOD-13125 | biostudies-arrayexpress
GenomicsBATF-JUN is critical for IRF4-mediated transcription in T cells
Interferon regulatory factor 4 (IRF4) is an IRF family transcription factor with critical roles in lymphoid development and in regulating the immune response. IRF4 binds DNA weakly owing to a carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in B cell...
ORGANISM(S): Mus musculus 
2012-09-18 | E-GEOD-39756 | biostudies-arrayexpress
MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
TranscriptomicsChIP-seq analyses of OCI-Ly10 cell lines transduced by doxycycline-inducible lentiviral vectors expressing SPI1 WT or mutant proteins
To characterize SPI1 mutant with respect to WT binding to DNA on a genome-wide scale
ORGANISM(S): Homo sapiens 
2019-05-01 | E-MTAB-7881 | biostudies-arrayexpress
ProteomicsIn vivo BioID Mouse heart masspec data
Cardiac excitation-contraction (E-C) coupling requires dyads, the nanoscopic microdomains formed adjacent to Z-lines by apposition of transverse (T)-tubules and junctional sarcoplasmic reticulum (jSR). Disruption of dyad architecture and function are common features of diseased cardiomyocytes. Howev...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-21 | PXD028960 | Pride
Mouse hearts Ca signaling Bioid Ryr2 
TranscriptomicsGene expression analysis of WT and Flt3-ITD multipotent progenitors
FLT3-ITDs Introduce a Myeloid Differentiation and Transformation Bias in Lympho-myeloid Multipotent Progenitors WT multipotent progenitors were compared with FLT3-ITD multipotent progenitors
ORGANISM(S): Mus musculus 
2014-05-16 | E-GEOD-35805 | biostudies-arrayexpress
GenomicsSupression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic spo11 allele
Homologous recombination is the key process that generates genetic diversity and drives evolution. SPO11 protein triggers recombination by introducing DNA double stranded breaks at discreet areas of the genome called recombination hotspots. The hotspot locations are largely determined by the DNA bin...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-48493 | biostudies-arrayexpress
TranscriptomicsRNA-seq analyses of OCI-Ly10 cell lines transduced by doxycycline-inducible lentiviral vectors expressing SPI1 WT or mutant proteins
To characterize the functional consequences of mutant or WT binding
ORGANISM(S): Homo sapiens 
2019-05-10 | E-MTAB-7910 | biostudies-arrayexpress
UnknownImproving the Damping Properties of Nanocomposites by Monodispersed Hybrid POSS Nanoparticles: Preparation and Mechanisms.
Not available
S-EPMC6523941 | biostudies-literature
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